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dc.contributor.authorOsbak, K.K.
dc.contributor.authorMeehan, Conor J.
dc.contributor.authorG. Ribas, S.
dc.contributor.authorHeyndrickx, L.
dc.contributor.authorAriën, K.K.
dc.contributor.authorTsoumanis, A.
dc.contributor.authorFlorence, E.
dc.contributor.authorEsbroeck, M.V.
dc.contributor.authorFransen, K.
dc.contributor.authorKenyon, C.R.
dc.date.accessioned2019-09-16T21:27:45Z
dc.date.accessioned2019-09-30T15:07:52Z
dc.date.available2019-09-16T21:27:45Z
dc.date.available2019-09-30T15:07:52Z
dc.date.issued2019-04
dc.identifier.citationOsbak KK, Meehan CJ, G Ribas S et al (2019) Superimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgium. International Journal of STD and AIDS. 30(5): 486-495.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17273
dc.descriptionNoen_US
dc.description.abstractIn this study, we assessed if the superimposition of incident sexually transmitted infections (STIs) on HIV phylogenetic analyses could reveal possible sexual behaviour misclassifications in our HIV-infected population. HIV-1 sequences collected between 1997 and 2014 from 1169 individuals attending a HIV clinic in Antwerp, Belgium were analysed to infer a partial HIV transmission network. Individual demographic, clinical and laboratory data collected during routine HIV follow-up were used to compare clustered and non-clustered individuals using logistic regression analyses. In total, 438 (37.5%) individuals were identified in 136 clusters, including 76 transmission pairs and 60 clusters consisting of three or more individuals. Individuals in a cluster were more likely to have a history of syphilis, Chlamydia and/or gonorrhoea (P < 0.05); however, when analyses were stratified by HIV transmission risk groups (heterosexual and men who have sex with men [MSM]), this association only remained significant for heterosexuals with syphilis (P = 0.001). Under closer scrutiny, this association was driven by six heterosexual men who were located in six almost exclusively MSM clusters. A parsimonious conclusion is that these six individuals were potentially misclassified as heterosexual. Improving the accuracy of sexual behaviour reporting could improve care.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1177/0956462418821752en_US
dc.subjectHIV epidemiologyen_US
dc.subjectHIV infectionen_US
dc.subjectMen who have sex with menen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectSexually transmitted infectionen_US
dc.subjectSyphilisen_US
dc.titleSuperimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgiumen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-11-30
dc.date.application2019-02-04
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
dc.date.updated2019-09-16T20:27:57Z


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