Show simple item record

dc.contributor.authorLaenen, B.
dc.contributor.authorTedder, Andrew
dc.contributor.authorNowak, M.D.
dc.contributor.authorToräng, P.
dc.contributor.authorWunder, J.
dc.contributor.authorWötsel, S.
dc.contributor.authorSteige, K.A.
dc.contributor.authorKourmpetis, Y.
dc.contributor.authorOdong, T.
dc.contributor.authorDrouzas, A.D.
dc.contributor.authorBink, M.C.A.M.
dc.contributor.authorÅgren, J.
dc.contributor.authorCoupland, G.
dc.contributor.authorSlotte, T.
dc.date.accessioned2019-09-13T09:44:35Z
dc.date.accessioned2019-09-27T08:56:24Z
dc.date.available2019-09-13T09:44:35Z
dc.date.available2019-09-27T08:56:24Z
dc.date.issued2018-01-23
dc.identifier.citationLaenen B, Tedder A, Nowak MD et al (2018) Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpina. Proceedings of the National Academy of Sciences. 115(4): 816-821.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17267
dc.descriptionYesen_US
dc.description.abstractPlant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer Arabis alpina. We find that outcrossing and mixed-mating populations maintain genetic diversity at similar levels, whereas highly self-fertilizing Scandinavian A. alpina show a strong reduction in genetic diversity, most likely as a result of a postglacial colonization bottleneck. We further find evidence for accumulation of genetic load in highly self-fertilizing populations, whereas the genome-wide impact of purifying selection does not differ greatly between mixed-mating and outcrossing populations. Our results demonstrate that intermediate levels of outcrossing may allow efficient selection against harmful alleles, whereas demographic effects can be important for relaxed purifying selection in highly selfing populations. Thus, mating system and demography shape the impact of purifying selection on genomic variation in A. alpina. These results are important for an improved understanding of the evolutionary consequences of mating system variation and the maintenance of mixed-mating strategies.
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1073/pnas.1707492115en_US
dc.subjectArabis alpinaen_US
dc.subjectSelf-fertilisationen_US
dc.subjectDemographic historyen_US
dc.subjectBottlenecken_US
dc.subjectFitness effectsen_US
dc.subjectGenetic loaden_US
dc.titleDemography and mating system shape the genome-wide impact of purifying selection in Arabis alpinaen_US
dc.status.refereedYesen_US
dc.date.Acceptedhttps://doi.org/10.1017/epi.2019.15
dc.date.application2018-01-04
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThis article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1707492115/-/DCSupplemental.en_US
dc.date.updated2019-09-13T08:44:36Z
refterms.dateFOA2019-09-27T09:28:29Z


Item file(s)

Thumbnail
Name:
laenen_et_al_2018.pdf
Size:
217.3Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record