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dc.contributor.authorMeehan, Conor J.
dc.contributor.authorBeiko, R.G.
dc.date.accessioned2019-09-10T10:05:44Z
dc.date.accessioned2019-09-26T09:36:11Z
dc.date.available2019-09-10T10:05:44Z
dc.date.available2019-09-26T09:36:11Z
dc.date.issued2014-03
dc.identifier.citationMeehan CJ and Beiko RG (2014) A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria. Genome Biology and Evolution. 6(3): 703-713.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17256
dc.descriptionYesen_US
dc.description.abstractSeveral bacterial families are known to be highly abundant within the human microbiome, but their ecological roles and evolutionary histories have yet to be investigated in depth. One such family, Lachnospiraceae (phylum Firmicutes, class Clostridia) is abundant in the digestive tracts of many mammals and relatively rare elsewhere. Members of this family have been linked to obesity and protection from colon cancer in humans, mainly due to the association of many species within the group with the production of butyric acid, a substance that is important for both microbial and host epithelial cell growth. We examined the genomes of 30 Lachnospiraceae isolates to better understand the origin of butyric acid capabilities and other ecological adaptations within this group. Butyric acid production-related genes were detected in fewer than half of the examined genomes with the distribution of this function likely arising in part from lateral gene transfer (LGT). An investigation of environment-specific functional signatures indicated that human gut-associated Lachnospiraceae possess genes for endospore formation, whereas other members of this family lack key sporulation-associated genes, an observation supported by analysis of metagenomes from the human gut, oral cavity, and bovine rumen. Our analysis demonstrates that adaptation to an ecological niche and acquisition of defining functional roles within a microbiome can arise through a combination of both habitat-specific gene loss and LGT.en_US
dc.description.sponsorshipCanadian Institute for Health Research (grant number CMF-108026), Genome Atlantic and the Canada Research Chairs program to R.G.B.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1093/gbe/evu050en_US
dc.rights(c) 2014 Oxford University Press. Full-text reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectLateral gene transferen_US
dc.subjectMicrobial genomesen_US
dc.subjectMetagenomicsen_US
dc.subjectPhylogenomicsen_US
dc.subjectButyric aciden_US
dc.titleA phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteriaen_US
dc.status.refereedYesen_US
dc.date.Accepted2014-03-04
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2019-09-10T09:05:46Z
refterms.dateFOA2019-09-26T09:37:13Z


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