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    A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria

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    Meehan_Lachno_GBE_2014.pdf (548.9Kb)
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    Publication date
    2014-03
    Author
    Meehan, Conor J.
    Beiko, R.G.
    Keyword
    Lateral gene transfer
    Microbial genomes
    Metagenomics
    Phylogenomics
    Butyric acid
    Rights
    (c) 2014 Oxford University Press. Full-text reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
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    Abstract
    Several bacterial families are known to be highly abundant within the human microbiome, but their ecological roles and evolutionary histories have yet to be investigated in depth. One such family, Lachnospiraceae (phylum Firmicutes, class Clostridia) is abundant in the digestive tracts of many mammals and relatively rare elsewhere. Members of this family have been linked to obesity and protection from colon cancer in humans, mainly due to the association of many species within the group with the production of butyric acid, a substance that is important for both microbial and host epithelial cell growth. We examined the genomes of 30 Lachnospiraceae isolates to better understand the origin of butyric acid capabilities and other ecological adaptations within this group. Butyric acid production-related genes were detected in fewer than half of the examined genomes with the distribution of this function likely arising in part from lateral gene transfer (LGT). An investigation of environment-specific functional signatures indicated that human gut-associated Lachnospiraceae possess genes for endospore formation, whereas other members of this family lack key sporulation-associated genes, an observation supported by analysis of metagenomes from the human gut, oral cavity, and bovine rumen. Our analysis demonstrates that adaptation to an ecological niche and acquisition of defining functional roles within a microbiome can arise through a combination of both habitat-specific gene loss and LGT.
    URI
    http://hdl.handle.net/10454/17256
    Version
    Published version
    Citation
    Meehan CJ and Beiko RG (2014) A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria. Genome Biology and Evolution. 6(3): 703-713.
    Link to publisher’s version
    https://doi.org/10.1093/gbe/evu050
    Type
    Article
    Collections
    Life Sciences Publications

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