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    Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

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    Publication date
    2019-07
    Author
    Shepherd, J.
    Swift, Thomas
    Chang, Chien-Yi
    Boyne, J.R.
    Rimmer, Stephen
    Martin, William H.C.
    Keyword
    Bacterial quorum sensing
    Biofilm formation
    Chromobacterium violaceum
    Rights
    (c) 2019 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
    URI
    http://hdl.handle.net/10454/17253
    Version
    Published version
    Citation
    Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S and Martin WHC (2019) Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum. Chemical Communications. 55(66): 9765-9768.
    Link to publisher’s version
    https://doi.org/10.1039/C9CC02524C
    Type
    Article
    Collections
    Life Sciences Publications

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