Show simple item record

dc.contributor.authorSantos, Ana R.N.
dc.contributor.authorSheldrake, Helen M.
dc.contributor.authorIbrahim, Ali I.M.
dc.contributor.authorDanta, Chhanda C.
dc.contributor.authorBonanni, D.
dc.contributor.authorDaga, M.
dc.contributor.authorOliaro-Bosso, s.
dc.contributor.authorBoschi, D.
dc.contributor.authorLolli, M.L.
dc.contributor.authorPors, Klaus
dc.date.accessioned2019-09-04T13:03:41Z
dc.date.accessioned2019-09-24T13:25:37Z
dc.date.available2019-09-04T13:03:41Z
dc.date.available2019-09-24T13:25:37Z
dc.date.issued2019-01
dc.identifier.citationSantos ARN, Sheldrake HM, Ibrahim AIM et al (2019) Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm. 10(8): 1476-1480.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17252
dc.descriptionYesen_US
dc.description.abstractTetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.en_US
dc.description.sponsorshipFundação para a Ciência, a Tecnologia (PhD studentship ARNS SFRH/BD/46871/2008), EPSRC (RCUK Academic Fellowship HMS), UniTO grant Ricerca Locale 2015 (grant number LOLM_RILO_17_01) and Fondazione Cassa di Risparmio di Torino (grant BOSD_CRT_17_2).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/C9MD00201Den_US
dc.rights(c) 2019 RSC. Full-text reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectTetrahydroisoquinolineen_US
dc.subjectTHIQen_US
dc.titleExploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinityen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-06-27
dc.date.application2019-06-27
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-09-04T12:03:44Z
refterms.dateFOA2019-09-24T13:37:44Z


Item file(s)

Thumbnail
Name:
Santosetal_MedChemComm2019_Fin ...
Size:
3.411Mb
Format:
Microsoft Word 2007

This item appears in the following Collection(s)

Show simple item record