Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
| dc.contributor.author | Santos, Ana R.N. | |
| dc.contributor.author | Sheldrake, Helen M. | |
| dc.contributor.author | Ibrahim, Ali I.M. | |
| dc.contributor.author | Danta, Chhanda C. | |
| dc.contributor.author | Bonanni, D. | |
| dc.contributor.author | Daga, M. | |
| dc.contributor.author | Oliaro-Bosso, s. | |
| dc.contributor.author | Boschi, D. | |
| dc.contributor.author | Lolli, M.L. | |
| dc.contributor.author | Pors, Klaus | |
| dc.date.accessioned | 2019-09-04T13:03:41Z | |
| dc.date.accessioned | 2019-09-24T13:25:37Z | |
| dc.date.available | 2019-09-04T13:03:41Z | |
| dc.date.available | 2019-09-24T13:25:37Z | |
| dc.date.issued | 2019-01 | |
| dc.identifier.citation | Santos ARN, Sheldrake HM, Ibrahim AIM et al (2019) Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm. 10(8): 1476-1480. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10454/17252 | |
| dc.description | Yes | en_US |
| dc.description.abstract | Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3. | en_US |
| dc.description.sponsorship | Fundação para a Ciência, a Tecnologia (PhD studentship ARNS SFRH/BD/46871/2008), EPSRC (RCUK Academic Fellowship HMS), UniTO grant Ricerca Locale 2015 (grant number LOLM_RILO_17_01) and Fondazione Cassa di Risparmio di Torino (grant BOSD_CRT_17_2). | en_US |
| dc.language.iso | en | en_US |
| dc.relation.isreferencedby | https://doi.org/10.1039/C9MD00201D | en_US |
| dc.rights | (c) 2019 RSC. Full-text reproduced in accordance with the publisher's self-archiving policy. | en_US |
| dc.subject | Tetrahydroisoquinoline | en_US |
| dc.subject | THIQ | en_US |
| dc.title | Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity | en_US |
| dc.status.refereed | Yes | en_US |
| dc.date.Accepted | 2019-06-27 | |
| dc.date.application | 2019-06-27 | |
| dc.type | Article | en_US |
| dc.type.version | Accepted manuscript | en_US |
| dc.date.updated | 2019-09-04T12:03:44Z | |
| refterms.dateFOA | 2019-09-24T13:37:44Z |
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