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    Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

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    Publication date
    2019-01
    Author
    Santos, Ana R.N.
    Sheldrake, Helen M.
    Ibrahim, Ali I.M.
    Danta, Chhanda C.
    Bonanni, D.
    Daga, M.
    Oliaro-Bosso, s.
    Boschi, D.
    Lolli, M.L.
    Pors, Klaus
    Keyword
    Tetrahydroisoquinoline
    THIQ
    Rights
    (c) 2019 RSC. Full-text reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
    URI
    http://hdl.handle.net/10454/17252
    Version
    Accepted manuscript
    Citation
    Santos ARN, Sheldrake HM, Ibrahim AIM et al (2019) Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm. 10(8): 1476-1480.
    Link to publisher’s version
    https://doi.org/10.1039/C9MD00201D
    Type
    Article
    Collections
    Life Sciences Publications

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