BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Serum level of IL-4 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    Accepted Manuscript (712.8Kb)
    Download
    Publication date
    2018
    Author
    Gong, Y.
    Zhao, Y.
    Zhang, X.
    Qi, S.
    Li, S.
    Ye, Y.
    Yang, J.
    Caulloo, S.
    McElwee, Kevin J.
    Zhang, X.
    Keyword
    Alopecia areata
    Biomarkers
    Diphenylcyclopropenone
    Prognostic
    Therapeutic effect
    Rights
    © 2018 Wiley This is the peer reviewed version of the following article: Gong Y, Zhao Y, Zhang X et al (2018) Serum level of IL-4 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata. Experimental Dermatology. 29:231-238, which has been published in final form at https://doi.org/10.1111/exd.13758. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Background: This study investigated predictors of response to topical diphenylyclopropenone (DPCP) immunotherapy in patients with alopecia areata (AA). Objective: To identify predictors of response, or resistance, to treatment for AA through clinical observations and serum tests. Methods: Eighty four AA patients were treated with DPCP. Serum cytokine levels were measured in 33 AA patients pre- and post-treatment, and in 18 healthy controls, using ELISA assays. Results: Of patients, 56.1% responded to DPCP with satisfactory hair regrowth; the response rate was negatively correlated with hair loss extent. Before DPCP treatment, higher serum IFN-γ and IL-12 cytokine levels were observed in AA patients compared to healthy controls. Non-responders to DPCP had significantly elevated serum IL-4 pre-treatment (3.07 fold higher) and lower IL-12 levels compared with responders. After DPCP treatment, non-responders had persistently high IL-4, increased IL-12, negligible decrease in IFN-γ and decreased IL-10. Post-treatment DPCP responders exhibited significantly decreased IFN-γ and IL-12, and increased IL-4 and IL-10. Development of adverse side-effects was significantly associated with higher pre-treatment serum IgE levels. Limitations: A small number of subjects were evaluated. Conclusions: Potentially, elevated pre-treatment serum levels of IL-4 and IL-12 can be used as unfavorable and favorable predictors of DPCP therapeutic effect, respectively. In addition, pre-treatment elevated serum total IgE may predict increased risk for severe adverse side-effects to DPCP application. Whether serum cytokine expression levels can be used as predictors of response to other forms of treatment is unknown, but it may warrant investigation in the development of personalized treatments for AA.
    URI
    http://hdl.handle.net/10454/17236
    Version
    Accepted manuscript
    Citation
    Gong Y, Zhao Y, Zhang X et al (2018) Serum level of IL-4 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata. Experimental Dermatology. 29:231-238.
    Link to publisher’s version
    https://doi.org/10.1111/exd.13758
    Type
    Article
    Collections
    Life Sciences Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.