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dc.contributor.authorZegke, Markus
dc.contributor.authorSpencer, H.L.M.
dc.contributor.authorLord, Rianne M.
dc.date.accessioned2019-08-29T09:35:32Z
dc.date.available2019-08-29T09:35:32Z
dc.date.issued2019
dc.identifier.citationZegke M, Spencer HLM and Lord RM (2019) Fast, facile solvent-free dry-melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cells. Chemistry: A European Journal. Accepted for Publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17232
dc.descriptionYesen_US
dc.description.abstractA range of oxobis(phenyl‐1,3‐butanedione) vanadium(IV) complexes have been successfully synthesized from cheap starting materials and a simple and solvent‐free one‐pot dry‐melt reaction. This direct, straightforward, fast and alternative approach to inorganic synthesis has the potential for a wide range of applications. Analytical studies confirm their successful synthesis, purity and solid‐state coordination, and we report the complexes’ uses as potential drug candidates for the treatment of cancer. After a 24‐hour incubation of A549 lung carcinoma cells with the compounds, they reveal cytotoxicity values 11‐fold greater than cisplatin, and remain non‐toxic towards normal cell types. Additionally, the complexes are stable over a range of physiological pH values and show the potential for interactions with BSA.en_US
dc.description.sponsorshipUniversity of Bradford. Grant Number: Internal Research Development Funden_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1002/chem.201902441en_US
dc.rights© 2019 Wiley This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at https://doi.org/10.1002/chem.201902441. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectBioinorganic chemistryen_US
dc.subjectCanceren_US
dc.subjectCoordination compoundsen_US
dc.subjectSolid-state synthesisen_US
dc.subjectVanadiumen_US
dc.subjectAntitumor agentsen_US
dc.titleFast, facile and solvent‐free dry melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cellsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-08-06
dc.date.application2019-08-06
dc.typeArticleen_US
dc.date.EndofEmbargo2020-08-07
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 7 Aug 2020.en_US
refterms.dateFOA2019-08-29T09:44:26Z


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