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dc.contributor.authorGuo, Xiaoxiao
dc.contributor.authorElkashelf, Sara M.
dc.contributor.authorLoadman, Paul M.
dc.contributor.authorPatterson, Laurence H.
dc.contributor.authorFalconer, Robert A.
dc.date.accessioned2019-08-08T15:00:01Z
dc.date.accessioned2019-08-14T11:47:34Z
dc.date.available2019-08-08T15:00:01Z
dc.date.available2019-08-14T11:47:34Z
dc.date.issued2019-11-15
dc.identifier.citationGuo X, Elkashef SM, Loadman PM et al (2019) Recent advances in the analysis of polysialic acid from complex biological systems. Carbohydrate Polymers. 224: 115145.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17206
dc.descriptionYesen_US
dc.description.abstractPolysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.carbpol.2019.115145en_US
dc.rightsCrown Copyright © 2019 Published by Elsevier Ltd. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectPolysialic aciden_US
dc.subjectGlycan analysisen_US
dc.subjectGlycan quantitationen_US
dc.titleRecent advances in the analysis of polysialic acid from complex biological systemsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-07-29
dc.date.application2019-08-03
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-08-08T14:00:08Z
refterms.dateFOA2019-08-14T11:48:06Z


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