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dc.contributor.authorDebnath, S.
dc.contributor.authorRoy, S.
dc.contributor.authorAbul-Haija, Y.M.
dc.contributor.authorFrederix, P.W.J.M.
dc.contributor.authorRamalhete, S.M.
dc.contributor.authorHirst, A.R.
dc.contributor.authorJavid, Nadeem
dc.contributor.authorHunt, N.T.
dc.contributor.authorKelly, S.M.
dc.contributor.authorAngulo, J.
dc.contributor.authorKhimyak, Y.Z.
dc.contributor.authorUlijn, R.V.
dc.date.accessioned2019-08-08T11:09:44Z
dc.date.accessioned2019-08-14T10:54:37Z
dc.date.available2019-08-08T11:09:44Z
dc.date.available2019-08-14T10:54:37Z
dc.date.issued2019-06-12
dc.identifier.citationDebnath S, Roy S, Abul-Haija YM et al (2019) Tunable supramolecular gel properties by varying thermal history. Chemistry: A European Journal. 25(33): 7881-7887.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17205
dc.descriptionYesen_US
dc.description.abstractThe possibility of using differential pre‐heating prior to supramolecular gelation to control the balance between hydrogen‐bonding and aromatic stacking interactions in supramolecular gels and obtain consequent systematic regulation of structure and properties is demonstrated. Using a model aromatic peptide amphiphile, Fmoc‐tyrosyl‐leucine (Fmoc‐YL) and a combination of fluorescence, infrared, circular dichroism and NMR spectroscopy, it is shown that the balance of these interactions can be adjusted by temporary exposure to elevated temperatures in the range 313–365 K, followed by supramolecular locking in the gel state by cooling to room temperature. Distinct regimes can be identified regarding the balance between H‐bonding and aromatic stacking interactions, with a transition point at 333 K. Consequently, gels can be obtained with customizable properties, including supramolecular chirality and gel stiffness. The differential supramolecular structures also result in changes in proteolytic stability, highlighting the possibility of obtaining a range of supramolecular architectures from a single molecular structure by simply controlling the pre‐assembly temperature.en_US
dc.description.sponsorshipFP7 Ideas: European Research Council. Grant Number: 258775en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1002/chem.201806281en_US
dc.rights© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Debnath S, Roy S, Abul-Haija YM et al (2019) Tunable supramolecular gel properties by varying thermal history. Chemistry: A European Journal. 25(33): 7881-7887, which has been published in final form at https://doi.org/10.1002/chem.201806281. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectHydrogelsen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectSelf-assemblyen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectThermal historyen_US
dc.titleTunable supramolecular gel properties by varying thermal historyen_US
dc.status.refereedYesen_US
dc.date.application2019-04-04
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-08-08T10:09:45Z
refterms.dateFOA2019-08-14T10:55:02Z


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