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dc.contributor.authorJove, M.
dc.contributor.authorSpencer, Jade A.
dc.contributor.authorClench, M.
dc.contributor.authorLoadman, Paul
dc.contributor.authorTwelves, C.
dc.date.accessioned2019-07-10T14:54:01Z
dc.date.accessioned2019-07-17T09:25:51Z
dc.date.available2019-07-10T14:54:01Z
dc.date.available2019-07-17T09:25:51Z
dc.date.issued2019-09
dc.identifier.citationJove M, Spencer J, Clench M et al (2019) Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance. Critical Reviews in Oncology/Hematology. 141: 153-162.
dc.identifier.urihttp://hdl.handle.net/10454/17170
dc.descriptionYes
dc.description.abstractFailure of systemic cancer treatment can be, at least in part, due to the drug not being delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous distribution; this is termed as “pharmacokinetic drug resistance”. To understand whether a drug is being adequately delivered to the tumour, “precision pharmacology” techniques are needed. Mass spectrometry imaging (MSI) is a relatively new and complex technique that allows imaging of drug distribution within tissues. In this review we address the applicability of MSI to the study of cancer drug distribution from the bench to the bedside. We address: (i) the role of MSI in pre-clinical studies to characterize anti-cancer drug distribution within the body and the tumour, (ii) the application of MSI in pre-clinical studies to define optimal drug dose or schedule, combinations or new drug delivery systems, and finally (iii) the emerging role of MSI in clinical research.
dc.description.sponsorshipSpanish Medical Oncology Society (SEOM) for contribution with a grant for research abroad of Dr. Jove, “Instituto Carlos III” for contribution with a “Río Hortega” Grant (nº CM17/00008) for Dr. Jove
dc.language.isoen
dc.rightsCrown Copyright © 2019 Published by Elsevier B.V. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
dc.subjectMALDI-MSI
dc.subjectIntra-tumoural drug distribution
dc.subjectDrug development
dc.subjectPharmacokinetics
dc.titlePrecision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance
dc.status.refereedYes
dc.date.Accepted2019-06-13
dc.date.application2019-07-05
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1016/j.critrevonc.2019.06.008
dc.rights.licenseCC-BY-NC-ND
dc.date.updated2019-07-10T13:54:05Z
refterms.dateFOA2019-07-17T09:26:36Z
dc.openaccess.statusopenAccess


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