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dc.contributor.authorMelo, P.
dc.contributor.authorTarrant, E.
dc.contributor.authorSwift, Thomas
dc.contributor.authorTownshend, A.
dc.contributor.authorGerman, M.
dc.contributor.authorFerreira, A-M.
dc.contributor.authorGentile, P.
dc.contributor.authorDalgarno, K.
dc.date.accessioned2019-07-01T15:21:39Z
dc.date.accessioned2019-07-03T11:21:03Z
dc.date.available2019-07-01T15:21:39Z
dc.date.available2019-07-03T11:21:03Z
dc.date.issued2019
dc.identifier.citationMelo P, Tarrant E, Swift T et al (2019) Short phosphate glass fiber - PLLA composite to promote bone mineralization. Materials Science and Engineering: C. Accepted for Publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17158
dc.descriptionYesen_US
dc.description.abstractThe clinical application of composites seeks to exploit the mechanical and chemical properties of materials which make up the composite, and in researching polymer composites for biomedical applications the aim is usually to enhance the bioactivity of the polymer, while maintaining the mechanical properties. To that end, in this study medical grade Poly(L-lactic) acid (PLLA) has been reinforced with short phosphate-based glass fibers (PGF). The materials were initially mixed by melting PLLA granules with the short fibers, before being extruded to form a homogenous filament, which was pelletized and used as feedstock for compression moulding. As made the composite materials had a bending strength of 51 MPa ± 5, and over the course of eight weeks in PBS the average strength of the composite material was in the range 20–50 MPa. Human mesenchymal stromal cells were cultured on the surfaces of scaffolds, and the metabolic activity, alkaline phosphatase production and mineralization monitored over a three week period. The short fiber filler made no significant difference to cell proliferation or differentiation, but had a clear and immediate osteoinductive effect, promoting mineralization by cells at the material surface. It is concluded that the PLLA/PGF composite material offers a material with both the mechanical and biological properties for potential application to bone implants and fixation, particularly where an osteoinductive effect would be valuable.en_US
dc.description.sponsorshipfunded in part by the EPSRC Centre for Doctoral Training in Additive Manufacturing and 3D Printing (EP/L01534X/1), the EPSRC Centre for Innovative Manufacture in Medical Devices (EP/K029592/1), and Glass Technology Services Ltd., Sheffield, UK.en_US
dc.language.isoenen_US
dc.publisherElsevier
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.msec.2019.109929en_US
dc.rights© 2019 Elsevier B.V. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectShort fiber compositeen_US
dc.subjectBoneen_US
dc.subjectCompression mouldingen_US
dc.subjectOsteoinductionen_US
dc.titleShort phosphate glass fiber - PLLA composite to promote bone mineralizationen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-06-27
dc.date.application2019-06-28
dc.typeArticleen_US
dc.date.EndofEmbargo2020-06-29
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 29 June 2020.en_US
dc.date.updated2019-07-01T14:21:50Z
refterms.dateFOA2019-07-03T11:22:25Z


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