Show simple item record

dc.contributor.authorHossain, S.I.
dc.contributor.authorGandhi, N.S.
dc.contributor.authorHughes, Zak E.
dc.contributor.authorGu, Y.T.
dc.contributor.authorSaha, S.C.
dc.date.accessioned2019-07-01T07:41:16Z
dc.date.accessioned2019-07-01T11:29:49Z
dc.date.available2019-07-01T07:41:16Z
dc.date.available2019-07-01T11:29:49Z
dc.date.issued2019-08-01
dc.identifier.citationHossain SI, Gandhi NS, Hughes ZE et al (2019) Molecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutants. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1861(8): 1458-1467.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17155
dc.descriptionYesen_US
dc.description.abstractInhaled nanoparticles (NPs) are experienced by the first biological barrier inside the alveolus known as lung surfactant (LS), a surface tension reducing agent, consisting of phospholipids and proteins in the form of the monolayer at the air-water interface. The monolayer surface tension is continuously regulated by the alveolus compression and expansion and protects the alveoli from collapsing. Inhaled NPs can reach deep into the lungs and interfere with the biophysical properties of the lung components. The interaction mechanisms of bare gold nanoparticles (AuNPs) with the LS monolayer and the consequences of the interactions on lung function are not well understood. Coarse-grained molecular dynamics simulations were carried out to elucidate the interactions of AuNPs with simplified LS monolayers at the nanoscale. It was observed that the interactions of AuNPs and LS components deform the monolayer structure, change the biophysical properties of LS and create pores in the monolayer, which all interfere with the normal lungs function. The results also indicate that AuNP concentrations >0.1 mol% (of AuNPs/lipids) hinder the lowering of the LS surface tension, a prerequisite of the normal breathing process. Overall, these findings could help to identify the possible consequences of airborne NPs inhalation and their contribution to the potential development of various lung diseases.en_US
dc.description.sponsorshipUniversity of Technology Sydney (UTS) FEIT Research Scholarship, UTS IRS (S.I.H.), 2018 Blue Sky scheme–Suvash Saha (Activity 2232368), N.S.G is supported by the Vice-Chancellor fellowship funded by QUT.en_US
dc.language.isoenen_US
dc.rights© 2019 Elsevier B.V. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectLung surfactanten_US
dc.subjectGold nanoparticlesen_US
dc.subjectSurface tensionen_US
dc.subjectCoarse-grained molecular dynamicsen_US
dc.subjectLipid monolayersen_US
dc.titleMolecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutantsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-06-06
dc.date.application2019-06-10
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.identifier.doihttps://doi.org/10.1016/j.bbamem.2019.06.001
dc.date.updated2019-07-01T06:41:29Z
refterms.dateFOA2019-07-01T11:31:31Z


Item file(s)

Thumbnail
Name:
1-s2.0-S0005273619301336-main.pdf
Size:
2.587Mb
Format:
PDF
Description:
Hughes_BBA_Biomembranes

This item appears in the following Collection(s)

Show simple item record