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dc.contributor.authorCheong, V-Lin*
dc.contributor.authorSowter, Julie*
dc.contributor.authorScally, Andy J.*
dc.contributor.authorHamilton, N.*
dc.contributor.authorAli, A.*
dc.contributor.authorSilcock, Jonathan*
dc.date.accessioned2019-05-29T08:32:46Z
dc.date.available2019-05-29T08:32:46Z
dc.date.issued2020-09
dc.identifier.citationCheong V-L, Sowter J, Scally AJ et al (2020) Medication-related risk factors and its association with repeated hospital admissions in frail elderly: A case control study. Research in Social and Administrative Pharmacy. 16(9): 1318-1322.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17076
dc.descriptionYesen_US
dc.description.abstractRepeated hospital admissions are prevalent in older people. The role of medication in repeated hospital admissions has not been widely studied. The hypothesis that medication-related risk factors for initial hospital admissions were also associated with repeated hospital admissions was generated. To examine the association between medication-related risk factors and repeated hospital admissions in older people living with frailty. A retrospective case-control study was carried out with 200 patients aged ≥75 years with unplanned medical admissions into a large teaching hospital in England between January and December 2015. Demographic, clinical, and medication-related data were obtained from review of discharge summaries. Statistical comparisons were made between patients with 3 or more hospital admissions during the study period (cases) and those with 2 or fewer admissions (controls). Regressions were performed to establish independent predictors of repeated hospital admissions. Participants had a mean age of 83.8 years (SD 5.68) and 65.5% were female. There were 561 admission episodes across the sample, with the main reasons for admissions recorded as respiratory problems (25%) and falls (17%). Univariate logistic regression revealed five medication-related risks to be associated with repeated hospital admissions: Hyper-polypharmacy (defined as taking ≥10 medications) (OR 2.50, p < 0.005); prescription of potentially inappropriate medications (PIMs) (OR 1.89; p < 0.05); prescription of a diuretic (OR 1.87; p < 0.05); number of high risk medication (OR 1.29; p < 0.05) and the number of 'when required' medication (OR 1.20; p < 0.05). However, the effects of these risk factors became insignificant when comorbid disease was adjusted for in a multivariable model. Medication-related risk factors may play an important role in future repeated admission risk prediction models. The modifiable nature of medication-related risks factors highlights a real opportunity to improve health outcomes.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.sapharm.2019.02.001en_US
dc.rights© 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.subjectMedication risksen_US
dc.subjectPolypharmacyen_US
dc.subjectInappropriate medicationen_US
dc.subjectPrediction modelen_US
dc.subjectRepeated hospital admissionsen_US
dc.titleMedication-related risk factors and its association with repeated hospital admissions in frail elderly: A case control studyen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-02-01
dc.date.application2019-02-14
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US


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