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dc.contributor.authorPrimon, Monika*
dc.contributor.authorHunter, K.D.*
dc.contributor.authorPandha, H.S.*
dc.contributor.authorMorgan, Richard*
dc.date.accessioned2019-05-09T13:02:53Z
dc.date.available2019-05-09T13:02:53Z
dc.date.issued2019-04
dc.identifier.citationPrimon M, Hunter KD, Pandha HS et al (2019) Kinase regulation of HOX transcription factors. Cancers. 11(4): 508.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17038
dc.descriptionYesen_US
dc.description.abstractThe HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell renewal. There have been extensive studies on the mechanism by which HOX proteins regulate transcription, with particular emphasis on their interaction with cofactors such as Pre-B-cell Leukaemia Homeobox (PBX) and Myeloid Ecotropic Viral Integration Site 1 (MEIS). However, significantly less is known of how the activity of HOX proteins is regulated. There is growing evidence that phosphorylation may play an important role in this context, and in this review, we draw together a number of important studies published over the last 20 years, and discuss the relevance of phosphorylation in the regulation and function of HOX proteins in development, evolution, cell cycle regulation, and cancer.en_US
dc.language.isoenen_US
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectHOXen_US
dc.subjectPhosphorylationen_US
dc.subjectEmbryonic patterningen_US
dc.subjectCell cycleen_US
dc.subjectCanceren_US
dc.titleKinase regulation of HOX transcription factorsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-04-07
dc.date.application2019-04-10
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.3390/cancers11040508
refterms.dateFOA2019-05-09T13:02:53Z


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