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    Kinase regulation of HOX transcription factors

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    Morgan_Cancers.pdf (662.3Kb)
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    Publication date
    2019-04
    Author
    Primon, Monika
    Hunter, K.D.
    Pandha, H.S.
    Morgan, Richard
    Keyword
    HOX
    Phosphorylation
    Embryonic patterning
    Cell cycle
    Cancer
    Rights
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Peer-Reviewed
    Yes
    
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    Abstract
    The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell renewal. There have been extensive studies on the mechanism by which HOX proteins regulate transcription, with particular emphasis on their interaction with cofactors such as Pre-B-cell Leukaemia Homeobox (PBX) and Myeloid Ecotropic Viral Integration Site 1 (MEIS). However, significantly less is known of how the activity of HOX proteins is regulated. There is growing evidence that phosphorylation may play an important role in this context, and in this review, we draw together a number of important studies published over the last 20 years, and discuss the relevance of phosphorylation in the regulation and function of HOX proteins in development, evolution, cell cycle regulation, and cancer.
    URI
    http://hdl.handle.net/10454/17038
    Version
    Published version
    Citation
    Primon M, Hunter KD, Pandha HS et al (2019) Kinase regulation of HOX transcription factors. Cancers. 11(4): 508.
    Link to publisher’s version
    https://doi.org/10.3390/cancers11040508
    Type
    Article
    Collections
    Life Sciences Publications

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