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dc.contributor.authorRathi, N.*
dc.contributor.authorParadkar, Anant R.*
dc.contributor.authorGaikar, V.G.*
dc.date.accessioned2019-05-03T14:08:47Z
dc.date.available2019-05-03T14:08:47Z
dc.date.issued2019-08
dc.identifier.citationRathi N, Paradkar AR and Gaikar VG (2019) Polymorphs of Curcumin and Its Cocrystals With Cinnamic Acid. Journal of Pharmaceutical Sciences. 108(8): 2505-2516.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17014
dc.descriptionYesen_US
dc.description.abstractWe report formation of polymorphs and new eutectics and cocrystals of curcumin, a sparingly water-soluble active component in turmeric, structurally similar to cinnamic acid. The curcumin polymorphs were formed using liquid antisolvent precipitation, where acetone acted as a solvent and water was used as the antisolvent. The metastable form 2 of curcumin was successfully prepared in varied morphology over a wide range of solvent-to-antisolvent ratio and under acidic pH conditions. We also report formation of new eutectics and cocrystals of curcumin with cinnamic acid acting as a coformer. The binary phase diagrams were studied using differential scanning calorimetry and predicted formation of the eutectics at the curcumin mole fraction of 0.15 and 0.33, whereas a cocrystal was formed at 0.3 mole fraction of curcumin in the curcumin–cinnamic acid mixture. The formation of the cocrystal was supported with X-ray powder diffraction, the enthalpy of fusion values, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrogen bond interaction between curcumin and cinnamic acid was predicted from Fourier-transform infrared spectra, individually optimized curcumin and cinnamic acid structures by quantum mechanical calculations using Gaussian-09 and their respective unit cell packing structures.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.xphs.2019.03.014en_US
dc.rights(c) 2019 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.subjectCurcuminen_US
dc.subjectCinnamic aciden_US
dc.subjectEutecticen_US
dc.subjectCocrystalen_US
dc.subjectPolymorphsen_US
dc.subjectAntisolvent precipitationen_US
dc.titlePolymorphs of Curcumin and Its Cocrystals With Cinnamic Aciden_US
dc.status.refereedYesen_US
dc.date.Accepted2019-03-14
dc.date.application2019-03-21
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US


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