BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Biosynthetic PCL-graft-collagen bulk material for tissue engineering applications

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    Sefat_Materials.pdf (7.215Mb)
    Download
    Publication date
    2017-06
    Author
    Gentile, P.
    McColgan-Bannon, K.
    Gianone, N.C.
    Sefat, Farshid
    Dalgarno, K.
    Ferreira, A.M.
    Keyword
    Biosynthetic
    Collagen
    Poly("-caprolactone)
    Conjugation
    Electrospinning
    Tissue engineering
    Rights
    © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Biosynthetic materials have emerged as one of the most exciting and productive fields in polymer chemistry due to their widespread adoption and potential applications in tissue engineering (TE) research. In this work, we report the synthesis of a poly(ε-caprolactone)-graft-collagen (PCL-g-Coll) copolymer. We combine its good mechanical and biodegradable PCL properties with the great biological properties of type I collagen as a functional material for TE. PCL, previously dissolved in dimethylformamide/dichloromethane mixture, and reacted with collagen using carbodiimide coupling chemistry. The synthesised material was characterised physically, chemically and biologically, using pure PCL and PCL/Coll blend samples as control. Infrared spectroscopy evidenced the presence of amide I and II peaks for the conjugated material. Similarly, XPS evidenced the presence of C–N and N–C=O bonds (8.96 ± 2.02% and 8.52 ± 0.63%; respectively) for PCL-g-Coll. Static contact angles showed a slight decrease in the conjugated sample. However, good biocompatibility and metabolic activity was obtained on PCL-g-Coll films compared to PCL and blend controls. After 3 days of culture, fibroblasts exhibited a spindle-like morphology, spreading homogeneously along the PCL-g-Coll film surface. We have engineered a functional biosynthetic polymer that can be processed by electrospinning.
    URI
    http://hdl.handle.net/10454/16998
    Version
    Published version
    Citation
    Gentile P, McColgan-Bannon K, Gianone NC et al (2017) Biosynthetic PCL-graft-collagen bulk material for tissue engineering applications. Materials. 10(7): 693.
    Link to publisher’s version
    https://doi.org/10.3390/ma10070693
    Type
    Article
    Collections
    Engineering and Informatics Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.