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    Fabrication and characterizations of hydrogels for cartilage repair

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    Publication date
    2017-09-26
    Author
    Kaur, Payal
    Khaghani, Seyed A.
    Oluwadamilola, Agbabiaka
    Khurshid, Z.
    Zafar, M.S.
    Mozafari, M.
    Youseffi, Mansour
    Sefat, Farshid
    Keyword
    Articular cartilege
    Chitosan
    Cross-linker
    Hydrogel
    Loss modulus
    Scaffold
    Storage modulus
    Swelling property
    Viscoelastic
    Rights
    ©2017 Kaur et al. This is an Open Access article distributed under the terms of the Creative Commons CC-BY-NC License , which permits unrestricted use, distribution, and build upon your work non-commercially (https://creativecommons.org/licenses/by-nc/4.0/)
    Peer-Reviewed
    Yes
    
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    Abstract
    Articular cartilage is a vascular tissue with limited repair capabilities, leaving an afflicted person in extreme pain. The tissue experiences numerous forces throughout its lifetime. This study focuses on development of a novel hydrogel composed of chitosan and β-glycerophosphate for articular cartilage repair. The aim of this study was to investigate the mechanical properties and swelling behaviour of a novel hydrogel composed of chitosan and β-glycerophosphate for cartilage repair. The mechanical properties were measured for compression forces. Mach-1 mechanical testing system was used to obtain storage and loss modulus for each hydrogel sample to achieve viscoelastic properties of fabricated hydrogels. Two swelling tests were carried out to compare water retaining capabilities of the samples. The hydrogel samples were made of five different concentrations of β-glycerophosphate cross-linked with chitosan. Each sample with different β-glycerophosphate concentration underwent sinusoidal compression forces at three different frequencies -0.1Hz, 0.316Hz and 1Hz. The result of mechanical testing was obtained as storage and loss modulus. Storage modulus represents the elastic component and loss modulus represents the viscosity of the samples. The results obtained for 1Hz were of interest because the knee experiences frequency of 1Hz during walking.
    URI
    http://hdl.handle.net/10454/16991
    Version
    Published version
    Citation
    Kaur P, Khaghani SA, Oluwadamilola A et al (2017) Fabrication and characterizations of hydrogels for cartilage repair. Tissue Engineering and Regenerative Medicine: Open Access. 2(6): 283-288.
    Link to publisher’s version
    https://doi.org/10.15406/atroa.2017.02.00051
    Type
    Article
    Collections
    Engineering and Informatics Publications

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