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dc.contributor.authorMohamadi, F.*
dc.contributor.authorEbrahimi-Barough, S.*
dc.contributor.authorNourani, M.R.*
dc.contributor.authorMansoori, K.*
dc.contributor.authorSalehi, M.*
dc.contributor.authorAlizadeh, A.A.*
dc.contributor.authorTavangar, S.M.*
dc.contributor.authorSefat, Farshid*
dc.contributor.authorSharifi, S.*
dc.contributor.authorAi, J.*
dc.date.accessioned2019-04-29T09:30:44Z
dc.date.available2019-04-29T09:30:44Z
dc.date.issued2018
dc.identifier.citationMohamadi F, Ebrahimi-Barough S, Nourani MR et al (2018) Enhanced sciatic nerve regeneration by human endometrial stem cells in an electrospun poly (ε-caprolactone)/collagen/NBG nerve conduit in rat. Artificial Cells, Nanomedicine, and Biotechnology. 46(8): 1731-1743.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16990
dc.descriptionNoen_US
dc.description.abstractIn recent years, for neurodegenerative diseases therapy, research has focused on the stem cells therapy. Due to promising findings in stem cell therapy, there are various sources of stem cells for transplantation in human. The aim of this study was to evaluate sciatic nerve regeneration in the rat after nerve transaction followed by human endometrial stem cells (hEnSCs) treatment into poly (e-caprolactone)/collagen/nanobioglass (PCL/collagen/NBG) nanofibrous conduits. After treatment of animals, the performance in motor and sensory tests, showed significant improvement in rats treated with hEnSCs as an autograft. H&E images provided from cross-sectional and, longitudinal-sections of the harvested regenerative nerve as well as immunohistochemistry results indicated that regenerative nerve fibres had been formed and accompanied with new blood vessels in the conduit cell group. Due to the advantage of high surface area for cell attachment, it is reported that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve the functional regeneration outcome, especially for longer nerve defect restoration. In conclusion, our results suggest that the PCL/collagen/NBG nanofibrous conduit filled with hEnSCs is a suitable strategy to improve nerve regeneration after a nerve transaction in rat.en_US
dc.description.sponsorshipIran National Science Foundation (INSF) grant number 95849510en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1080/21691401.2017.1391823en_US
dc.subjectTissue engineeringen_US
dc.subjectHuman endometrial stem cellsen_US
dc.subjectElectrospinningen_US
dc.subjectNanofibrous conduitsen_US
dc.subjectNerve regenerationen_US
dc.titleEnhanced sciatic nerve regeneration by human endometrial stem cells in an electrospun poly (ε-caprolactone)/collagen/NBG nerve conduit in raten_US
dc.status.refereedYesen_US
dc.date.Accepted2017-10-10
dc.date.application2017-11-08
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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