Enhanced sciatic nerve regeneration by human endometrial stem cells in an electrospun poly (ε-caprolactone)/collagen/NBG nerve conduit in rat
Publication date
2018Author
Mohamadi, F.Ebrahimi-Barough, S.
Nourani, M.R.
Mansoori, K.
Salehi, M.
Alizadeh, A.A.
Tavangar, S.M.
Sefat, Farshid
Sharifi, S.
Ai, J.
Keyword
Tissue engineeringHuman endometrial stem cells
Electrospinning
Nanofibrous conduits
Nerve regeneration
Peer-Reviewed
Yes
Metadata
Show full item recordAbstract
In recent years, for neurodegenerative diseases therapy, research has focused on the stem cells therapy. Due to promising findings in stem cell therapy, there are various sources of stem cells for transplantation in human. The aim of this study was to evaluate sciatic nerve regeneration in the rat after nerve transaction followed by human endometrial stem cells (hEnSCs) treatment into poly (e-caprolactone)/collagen/nanobioglass (PCL/collagen/NBG) nanofibrous conduits. After treatment of animals, the performance in motor and sensory tests, showed significant improvement in rats treated with hEnSCs as an autograft. H&E images provided from cross-sectional and, longitudinal-sections of the harvested regenerative nerve as well as immunohistochemistry results indicated that regenerative nerve fibres had been formed and accompanied with new blood vessels in the conduit cell group. Due to the advantage of high surface area for cell attachment, it is reported that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve the functional regeneration outcome, especially for longer nerve defect restoration. In conclusion, our results suggest that the PCL/collagen/NBG nanofibrous conduit filled with hEnSCs is a suitable strategy to improve nerve regeneration after a nerve transaction in rat.Version
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Mohamadi F, Ebrahimi-Barough S, Nourani MR et al (2018) Enhanced sciatic nerve regeneration by human endometrial stem cells in an electrospun poly (ε-caprolactone)/collagen/NBG nerve conduit in rat. Artificial Cells, Nanomedicine, and Biotechnology. 46(8): 1731-1743.Link to Version of Record
https://doi.org/10.1080/21691401.2017.1391823Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1080/21691401.2017.1391823