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dc.contributor.authorMohammadi, A.*
dc.contributor.authorMaleki-Jamshid, A.*
dc.contributor.authorSanooghi, D.*
dc.contributor.authorMilan, P.B.*
dc.contributor.authorRahmani, A.*
dc.contributor.authorSefat, Farshid*
dc.contributor.authorShahpasand, K.*
dc.contributor.authorSoleimani, Morteza*
dc.contributor.authorBakhtiari, M.*
dc.contributor.authorBelali, R.*
dc.contributor.authorFaghihi, F.*
dc.contributor.authorJoghataei, M.T.*
dc.contributor.authorPerry, G.*
dc.contributor.authorMozafari, M.*
dc.date.accessioned2019-04-26T14:58:35Z
dc.date.available2019-04-26T14:58:35Z
dc.date.issued2018-01
dc.identifier.citationMohammadi A, Maleki-Jamshid A, Sanooghi D et al (2018) Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders. Molecular Neurobiology. 56(1): 307-318.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16987
dc.descriptionNoen_US
dc.description.abstractA neurological disorder is any disorder or abnormality in the nervous system. Among different neurological disorders, Alzheimer’s disease (AD) is recognized as the sixth leading cause of death globally. Considerable research has been conducted to find pioneer treatments for this devastating disorder among which cell therapy has attracted remarkable attentions over the last decade. Up to now, targeted differentiation into specific desirable cell types has remained a major obstacle to clinical application of cell therapy. Also, potential risks including uncontrolled growth of stem cells could be disastrous. In our novel protocol, we used basal forebrain cholinergic progenitor cells (BFCN) derived from human chorion-derived mesenchymal stem cells (hC-MSCs) which made it possible to obtain high-quality population of cholinergic neurons and in vivo in much shorter time period than previous established methods. Remarkably, the transplanted progenitors fully differentiated to cholinergic neurons which in turn integrated in higher cortical networks of host brains, resulting in significant improvement in cognitive assessments. This method may have profound implications in cell therapies for any other neurodegenerative disorders.en_US
dc.description.sponsorshipThis work was carried outwithin the framework of a collaborative project (Project Grant No. 94-02-30-25922) by the School of Medicine, Iran University of Medical Sciences, (Project Grant No. REP209) council for stem cell sciences and technologies (Presidency of the Islamic Republic of Iran, vice-presidency for science and technology), and Iran National Science Foundation (INSF).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1007/s12035-018-0968-1en_US
dc.subjectNeurological disorderen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectStem cellsen_US
dc.subjectBasal forebrain cholinergic progenitor cellsen_US
dc.titleTransplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disordersen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-02-16
dc.date.application2018-03-16
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
refterms.dateFOA2019-04-26T14:58:35Z


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