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dc.contributor.authorHeaven, A.*
dc.contributor.authorBrown, L.*
dc.contributor.authorYoung, J.*
dc.contributor.authorTeale, E.*
dc.contributor.authorHawkins, R.*
dc.contributor.authorSpilsbury, K.*
dc.contributor.authorMountain, Gail*
dc.contributor.authorYoung, T.*
dc.contributor.authorGoodwin, V.*
dc.contributor.authorHanratty, B.*
dc.contributor.authorChew-Graham, C.*
dc.contributor.authorBrundle, C.*
dc.contributor.authorMahmood, F.*
dc.contributor.authorJacob, I.*
dc.contributor.authorDaffu-O'Reilly, A.*
dc.contributor.authorClegg, A.*
dc.date.accessioned2019-03-25T15:07:23Z
dc.date.available2019-03-25T15:07:23Z
dc.date.issued2019-03
dc.identifier.citationHeaven A, Brown L, Young J et al (2019) Community ageing research 75+ study (CARE75+): an experimental ageing and frailty research cohort. BMJ Open. 9(3): e026744.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16915
dc.descriptionYesen_US
dc.description.abstractIntroduction The Community Ageing Research 75+ Study (CARE75+) is a longitudinal cohort study collecting an extensive range of health, social and economic data, with a focus on frailty, independence and quality of life in older age. CARE75+ is the first international experimental frailty research cohort designed using Trial within Cohorts (TwiCs) methodology, to align applied epidemiological research with clinical trial evaluation of interventions to improve the health and well-being of older people living with frailty. Methods and analysis Prospective cohort study using a TwiCs design. One thousand community-dwelling older people (≥75 years) will be recruited from UK general practices. Nursing home residents, those with an estimated life expectancy of 3 months or less and people receiving palliative care will be excluded. Data collection assessments will be face to face in the person’s home at baseline, 6 months, 12 months, 24 months and 48 months, including assessments of frailty, cognition, mood, health-related quality of life, comorbidity, medications, resilience, loneliness, pain and self-efficacy. A modified protocol for follow-up by telephone or web based will be offered at 6 months. Consent will be sought for data linkage and invitations to additional studies, including intervention studies using the TwiCs design. A blood sample biobank will be established for future basic science studies. Ethics and dissemination CARE75+ was approved by the NRES Committee Yorkshire and the Humber—Bradford Leeds 10 October 2014 (14/YH/1120). Formal written consent is sought if an individual is willing to participate and has capacity to provide informed consent. Consultee assent is sought if an individual lacks capacity. Study results will be disseminated in peer-reviewed scientific journals and scientific conferences. Key study results will be summarised and disseminated to all study participants via newsletters, local older people’s publications and local engagement events. Results will be reported on a bespoke CARE75+ website.en_US
dc.description.sponsorshipNIHR CLAHRC Yorkshire and Humber - www.clahrc-yh.nihr.ac.uk (study funding number IS-CLA-0113-10020) and supported by the NIHR CLAHRC South West Peninsula and West Midlands CLAHRC.en_US
dc.language.isoenen_US
dc.rights© Author(s) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectCommunity Ageing Research 75+ Study (CARE75+)en_US
dc.subjectLongitudinal cohort studyen_US
dc.subjectFrailtyen_US
dc.subjectIndependenceen_US
dc.subjectQuality of lifeen_US
dc.titleCommunity ageing research 75+ study (CARE75+): an experimental ageing and frailty research cohorten_US
dc.status.refereedYesen_US
dc.date.Accepted2019-01-21
dc.date.application2019-03-07
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2018-026744
refterms.dateFOA2019-03-25T15:07:23Z


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