Show simple item record

dc.contributor.authorKhan, A.*
dc.contributor.authorKamran, S.*
dc.contributor.authorAkhtar, N.*
dc.contributor.authorPonirakis, G.*
dc.contributor.authorAl-Muhannadi, H.*
dc.contributor.authorPetropoulos, I.N.*
dc.contributor.authorAl-Fahdawi, Shumoos*
dc.contributor.authorQahwaji, Rami S.R.*
dc.contributor.authorSartaj, F.*
dc.contributor.authorBabu, B.*
dc.contributor.authorWadiwala, M.F.*
dc.contributor.authorShuaib, A.*
dc.contributor.authorMailk, R.A.*
dc.date.accessioned2019-03-15T12:23:38Z
dc.date.available2019-03-15T12:23:38Z
dc.date.issued2018-11
dc.identifier.citationKhan A, Kamran S, Akhtar N et al (2018) Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke. Scientific Reports. 8:17333.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16894
dc.descriptionYesen_US
dc.description.abstractEndothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001) and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017, P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent association between corneal endothelial cell density, area and perimeter with acute ischemic stroke and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to identify patients at risk of acute ischemic stroke.en_US
dc.description.sponsorshipQatar National Research Fund Grant BMRP20038654en_US
dc.language.isoenen_US
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectCerebrovascular diseaseen_US
dc.subjectIschemic strokeen_US
dc.subjectCorneal confocal microscopy (CCM)en_US
dc.subjectCorneal endothelial cellsen_US
dc.subjectNerve fibresen_US
dc.titleCorneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic strokeen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-10-23
dc.date.application2018-11-26
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1038/s41598-018-35298-3
refterms.dateFOA2019-03-15T12:23:38Z


Item file(s)

Thumbnail
Name:
Qahwaji_Scientific_Reports.pdf
Size:
2.958Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record