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    Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke

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    Qahwaji_Scientific_Reports.pdf (2.958Mb)
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    Publication date
    2018-11
    Author
    Khan, A.
    Kamran, S.
    Akhtar, N.
    Ponirakis, G.
    Al-Muhannadi, H.
    Petropoulos, I.N.
    Al-Fahdawi, Shumoos
    Qahwaji, Rami S.R.
    Sartaj, F.
    Babu, B.
    Wadiwala, M.F.
    Shuaib, A.
    Mailk, R.A.
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    Keyword
    Endothelial dysfunction
    Cerebrovascular disease
    Ischemic stroke
    Corneal confocal microscopy (CCM)
    Corneal endothelial cells
    Nerve fibres
    Rights
    Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
    Peer-Reviewed
    Yes
    
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    Abstract
    Endothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001) and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017, P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent association between corneal endothelial cell density, area and perimeter with acute ischemic stroke and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to identify patients at risk of acute ischemic stroke.
    URI
    http://hdl.handle.net/10454/16894
    Version
    Published version
    Citation
    Khan A, Kamran S, Akhtar N et al (2018) Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke. Scientific Reports. 8:17333.
    Link to publisher’s version
    https://doi.org/10.1038/s41598-018-35298-3
    Type
    Article
    Collections
    Engineering and Informatics Publications

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