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    Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant Nile red and chain end vancomycin for the detection of Gram-positive bacteria

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    Swift_et_al_Acta_Biomaterialia_Final.pdf (2.078Mb)
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    Publication date
    2019-03-15
    Author
    Swift, Thomas
    Katsikogianni, Maria G.
    Hoskins, Richard
    Teratarantorn, P.
    Douglas, I.
    MacNeil, S.
    Rimmer, Stephen
    Keyword
    Bacterial sensor
    Stimuli responsive
    Solvatochromism
    Polymer architecture
    Specificity
    Diagnostic device
    Rights
    © 2019 Acta Materialia Inc. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    This study shows how highly branched poly(N-isopropyl acrylamide) (HB-PNIPAM) with a chain pendant solvatochromic dye (Nile red) could provide a fluorescence signal, as end groups bind to bacteria and chain segments become desolvated, indicating the presence of bacteria. Vancomycin was attached to chain ends of HB-PNIPAM or as pendant groups on linear polymers each containing Nile red. Location of the dye was varied between placement in the core of the branched polymer coil or the outer domains. Both calorimetric and fluorescence data showed that branched polymers responded to binding of both the peptide target (D-Ala-D-Aa) and bacteria in a different manner than analogous linear polymers; binding and response was more extensive in the branched variant. The fluorescence data showed that only segments located in the outer domains of branched polymers responded to binding of Gram-positive bacteria with little response when linear analogous polymer or branched polymer with the dye in the inner core was exposed to Staphylococcus aureus.
    URI
    http://hdl.handle.net/10454/16822
    Version
    Published version
    Citation
    Swift T, Katsikogianni M, Hoskins R et al (2019) Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant Nile red and chain end vancomycin for the detection of Gram-positive bacteria. Acta Biomaterialia. 87: 197-206.
    Link to publisher’s version
    https://doi.org/10.1016/j.actbio.2019.01.066
    Type
    Article
    Collections
    Life Sciences Publications

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