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dc.contributor.authorVaportzis, Ria*
dc.contributor.authorNiechcial, M.A.*
dc.contributor.authorGow, A.J.*
dc.date.accessioned2019-02-14T12:46:40Z
dc.date.available2019-02-14T12:46:40Z
dc.date.issued2019-03
dc.identifier.citationVaportzis E, Niechcial MA and Gow AJ (2019) A systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adults. Ageing Research Reviews. 50: 110-130.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16796
dc.descriptionYesen_US
dc.description.abstractActivities running in community-based-settings offer a method of delivering multimodal interventions to older adults beyond cognitive training programmes. This systematic review and meta-analysis investigated the impact of randomised controlled trials (RCTs) of ‘real-world’ interventions on the cognitive abilities of healthy older adults. Database searches were performed between October 2016 and September 2018. Forty-three RCTs were eligible for inclusion with 2826 intervention participants and 2234 controls. Interventions to enhance cognitive ability consisted of participation in activities that were physical (25 studies), cognitive (9 studies), or mixed (i.e., physical and cognitive; 7 studies), and two studies used other interventions that included older adults assisting schoolchildren and engagement via social network sites. Meta-analysis revealed that Trail Making Test (TMT) A, p =  0.05, M = 0.43, 95% CI [-0.00, 0.86], digit symbol substitution, p =  0.05, M = 0.30, 95% CI [0.00, 0.59], and verbal fluency, p =  0.04, M = 0.31, 95% CI [0.02, 0.61], improved after specific types of interventions versus the control groups (which were either active, wait-list or passive controls). When comparing physical activity interventions against all control groups, TMT A, p =  0.04, M = 0.25, 95% CI [0.01, 0.48], and digit span forward, p =  0.05, M = 0.91, 95% CI [-0.00, 1.82], significantly improved. Results remained non-significant for all outcomes when comparing cognitive activity interventions against all control groups. Results therefore suggest that healthy older adults are more likely to see cognitive improvements when involved in physical activity interventions. In addition, TMT A was the only measure that consistently showed significant improvements following physical activity interventions. Visuospatial abilities (as measured by TMT A) may be more susceptible to improvement following physical activity-based interventions, and TMT A may be a useful tool for detecting differences in that domain.en_US
dc.description.sponsorshipVelux Stiftung, Switzerland, (Project No. 1034)en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.arr.2019.01.006en_US
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/lienses/BY-NC-ND/4.0/)en_US
dc.subjectSystematic reviewen_US
dc.subjectMeta-analysisen_US
dc.subjectCognitive ageingen_US
dc.subjectCommunity-based interventionsen_US
dc.subjectHealthy older adultsen_US
dc.titleA systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adultsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-01-08
dc.date.application2019-01-29
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2019-02-14T12:46:40Z


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