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dc.contributor.authorNasr, M.*
dc.contributor.authorKarandikar, H.*
dc.contributor.authorAbdel-Aziz, R.T.A.*
dc.contributor.authorMoftah, N.*
dc.contributor.authorParadkar, Anant R.*
dc.date.accessioned2018-11-30T14:19:04Z
dc.date.accessioned2019-01-09T11:27:00Z
dc.date.available2018-11-30T14:19:04Z
dc.date.available2019-01-09T11:27:00Z
dc.date.issued2018-11-15
dc.identifier.citationNasr M, Karandikar H, Abdel-Aziz RTA et al (2018) Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne. Expert Opinion on Drug Delivery. 15(12): 1165-1173.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16734
dc.descriptionNo
dc.description.abstractHot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases. The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. The extrudates were characterized using DSC, FTIR, XRD, and DVS. The extrudates were also tested for their skin adhesion potential, ability to deposit nicotinamide in different skin layers, and their clinical efficacy in acne patients. The 10% nicotinamide extrudates exhibited amorphous nature which was reserved during storage, with no chemical interaction between nicotinamide and Soluplus. Upon contrasting the skin adhesion and drug deposition of extrudates and nicotinamide gel, it was evident that the extrudates displayed significantly higher adhesion and drug deposition reaching 4.8 folds, 5.3 folds, and 4.3 folds more in the stratum corneum, epidermis and dermis, respectively. Furthermore, the extrudates significantly reduced the total number of acne lesions in patients by 61.3% compared to 42.14% with the nicotinamide gel. Soluplus extrudates are promising topical drug delivery means for the treatment of dermatological diseases.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis
dc.relation.isreferencedbyhttps://doi.org/10.1080/17425247.2018.1546287en_US
dc.subjectNicotinamideen_US
dc.subjectAcneen_US
dc.subjectTopical extrudatesen_US
dc.subjectSoluplusen_US
dc.subjectHot melt extrusionen_US
dc.titleNovel nicotinamide skin-adhesive hot melt extrudates for treatment of acneen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-11-06
dc.date.application2018-11-09
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
dc.date.updated2018-11-30T14:19:07Z


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