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    Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne

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    Publication date
    2018-11-15
    Author
    Nasr, M.
    Karandikar, H.
    Abdel-Aziz, R.T.A.
    Moftah, N.
    Paradkar, Anant R.
    Keyword
    Nicotinamide
    Acne
    Topical extrudates
    Soluplus
    Hot melt extrusion
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Hot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases. The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. The extrudates were characterized using DSC, FTIR, XRD, and DVS. The extrudates were also tested for their skin adhesion potential, ability to deposit nicotinamide in different skin layers, and their clinical efficacy in acne patients. The 10% nicotinamide extrudates exhibited amorphous nature which was reserved during storage, with no chemical interaction between nicotinamide and Soluplus. Upon contrasting the skin adhesion and drug deposition of extrudates and nicotinamide gel, it was evident that the extrudates displayed significantly higher adhesion and drug deposition reaching 4.8 folds, 5.3 folds, and 4.3 folds more in the stratum corneum, epidermis and dermis, respectively. Furthermore, the extrudates significantly reduced the total number of acne lesions in patients by 61.3% compared to 42.14% with the nicotinamide gel. Soluplus extrudates are promising topical drug delivery means for the treatment of dermatological diseases.
    URI
    http://hdl.handle.net/10454/16734
    Version
    No full-text in the repository
    Citation
    Nasr M, Karandikar H, Abdel-Aziz RTA et al (2018) Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne. Expert Opinion on Drug Delivery. 15(12): 1165-1173.
    Link to publisher’s version
    https://doi.org/10.1080/17425247.2018.1546287
    Type
    Article
    Collections
    Life Sciences Publications

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