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    Evaluation of Alangium lamarckii bark for antiplasmodial and cytotoxic constituents and isolation of a novel tubulosine analogue

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    Publication date
    2018-10
    Author
    Kantamreddi, Venkata Siva Satya Narayana
    Marston, G.
    Shnyder, Steven D.
    Wright, Colin W.
    Keyword
    Indian medicinal plants
    Alangium lamarckii
    Ethnopharmacology
    Alkaloids
    Tubulosatine
    Malaria
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Alangium lamarkii is traditionally used in India for the treatment of malaria. Partial activity guided-fractionation of the basic chloroform fraction of the methanolic extract of the bark led to the isolation of a novel tubulosine analogue, 10-demethyl-9ˊ-N-methyltubulosine (1), for which the trivial name tubulosatine is suggested. In addition, the known A. lamarkii constituents, tubulosine (2), cephaeline and emetine were isolated as potent antiplasmodial and cytotoxic constituents, but 1 was up to 1000-fold less potent than the former alkaloids against both malaria parasites and human cancer cell lines. The compounds were active against both chloroquine-sensitive and chloroquine-resistant malaria parasites, but no selective toxicity was observed towards malaria parasites compared with cancer cells with any of the alkaloids. Further work to explore the basis for the relatively weak biological activities of 1 would be worthwhile. Betulinic acid, stigmasterol and its 3-O-glucoside were isolated from the neutral chloroform fraction of the methanolic extract.
    URI
    http://hdl.handle.net/10454/16707
    Version
    No full-text in the repository
    Citation
    Kantamreddi VSSN, Marston G, Shnyder SD et al (2018) Evaluation of Alangium lamarckii bark for antiplasmodial and cytotoxic constituents and isolation of a novel tubulosine analogue. Natural Products Communications. 13(10): 1283-1285.
    Link to publisher’s version
    http://www.naturalproduct.us/
    Type
    Article
    Collections
    Life Sciences Publications

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