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dc.contributor.authorOkeyo, Clint*
dc.contributor.authorChowdhury, D.F.*
dc.contributor.authorCheung, K.*
dc.contributor.authorRahmanian, Nejat*
dc.date.accessioned2018-12-14T14:44:43Z
dc.date.available2018-12-14T14:44:43Z
dc.date.issued2019-02-15
dc.identifier.citationOkeyo C, Chowdhury DF, Cheung K et al (2019) 3D printed elastic mould granulation. Powder Technology. 344: 380-392.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16700
dc.descriptionYesen_US
dc.description.abstractIn the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the aim of achieving enhanced process understating, a novel approach for granulation of fine powders is presented. First, a mould with the desired particle shape and size is created using 3D printing followed by casting using elastomeric material. The formulation is prepared through wet massing and tested as a thin film on flat elastomeric membranes. The thin film itself can be a product but it also gives a good indication of coating performance before coating the patterned elastic membrane with the formulation i.e., 3D printed elastic mould granulation. Results show that following granulation and drying, granules of controlled size and shape (e.g. cubic and 500 μm), strength, friability and flowability can be formed. The method presented may allow for more robust process development in particle engineering.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.powtec.2018.12.009en_US
dc.rights© 2018 Elsevier B.V. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectContinuousen_US
dc.subjectGranulationen_US
dc.subjectElasticen_US
dc.subjectMouldingen_US
dc.subjectThin-filmen_US
dc.subjectResearch Development Fund Publication Prize Award
dc.title3D printed elastic mould granulationen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-12-03
dc.date.application2018-12-04
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.description.publicnotesResearch Development Fund Publication Prize Award winner, December 2018.
refterms.dateFOA2018-12-14T14:44:43Z


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