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dc.contributor.authorAnees, Muhammad
dc.contributor.authorNayak, Sanjit
dc.contributor.authorAfarinkia, Kamya
dc.contributor.authorVinader, Victoria
dc.date.accessioned2018-12-05T15:56:58Z
dc.date.available2018-12-05T15:56:58Z
dc.date.issued2018-11
dc.identifier.citationAnees M, Nayak S, Afarinkia K et al (2018) Control of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide C. RSC Advances. 8(69): 39691-39695.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16691
dc.descriptionYesen_US
dc.description.abstractThe stereochemical outcome of the epoxidation of Δ14–15 cholestanes with mCPBA is controlled by the steric bulk of a C17 substituent. When the C17 is in the β configuration, the epoxide is formed in the α face, whereas if the C17 is trigonal (flat) or the substituent is in the α configuration, the epoxide is formed in the β face. The presence of a hydroxyl substituent at C20 does not influence the stereochemical outcome of the epoxidation.en_US
dc.description.sponsorshipWe thank University of Bradford for a bursary (MA).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/c8ra08540den_US
dc.rights© The Royal Society of Chemistry 2018. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licenceen_US
dc.subjectStereochemistryen_US
dc.subjectEpoxidationen_US
dc.subjectC14 hydroxylen_US
dc.titleControl of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide Cen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-11-16
dc.date.application2018-11-27
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-12-05T15:56:58Z


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