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dc.contributor.authorLiu, Xiangli*
dc.contributor.authorZhang, K.*
dc.contributor.authorAbraham, M.H.*
dc.date.accessioned2018-11-26T15:22:57Z
dc.date.available2018-11-26T15:22:57Z
dc.date.issued2018-10-15
dc.identifier.citationLiu X, Zhang K and Abraham MH (2018) Linear free energy relationship analysis of permeability across polydimethylsiloxane (PDMS) membranes and comparison with human skin permeation in vitro. European Journal of Pharmaceutical Sciences. 123: 524-530.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16670
dc.descriptionNoen_US
dc.description.abstractThe aim of the present work is to evaluate the similarity between PDMS membranes and human skin in vitro in permeation study by linear free energy relationship (LFER) analyses. The values of the permeability coefficient log Kp (cm/s) under reliable experimental conditions were collected from the literature for a set of 94 compounds including both neutral and ionic species, which cover a broad range of structural diversity. The values of log Kp (cm/s) have been correlated with Abraham descriptors to yield an equation with R2 = 0.952 and SD = 0.38 log units. The established LFER model for log Kp (cm/s) across PDMS membranes showed no close analogy with that through human skin in vitro. A further critical analysis of the coefficients of the LFER models confirmed that the PDMS permeation system is a very poor model for human skin permeation.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ejps.2018.08.012en_US
dc.subjectPolydimethylsiloxane (PDMS) membraneen_US
dc.subjectHuman skinen_US
dc.subjectPermeabilityen_US
dc.subjectLinear free energy relationships (LFER)en_US
dc.subjectAbraham descriptorsen_US
dc.titleLinear free energy relationship analysis of permeability across polydimethylsiloxane (PDMS) membranes and comparison with human skin permeation in vitroen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-08-09
dc.date.application2018-08-11
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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