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dc.contributor.authorClay, F.J.*
dc.contributor.authorKuriakose, A.*
dc.contributor.authorLesche, D.*
dc.contributor.authorHicks, A.J.*
dc.contributor.authorZaman, Hadar*
dc.contributor.authorAzizi, E.*
dc.contributor.authorPonsford, J.L.*
dc.contributor.authorJayaram, M.*
dc.contributor.authorHopwood, M.*
dc.date.accessioned2018-11-21T11:44:37Z
dc.date.available2018-11-21T11:44:37Z
dc.date.issued2018
dc.identifier.citationClay FJ, Kuriakose A, Lesche D, et al. (2018) Klüver-Bucy Syndrome following traumatic brain injury: a systematic synthesis and review of pharmacological treatment from cases in adolescents and adults. The Journal of Neuropsychiatry and Clinical Neurosciences. 31(1): 6-16.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16661
dc.descriptionYes
dc.description.abstractKlüver-Bucy syndrome (KBS) is a rare clinical presentation following traumatic brain injury (TBI). Symptoms include visual agnosia, placidity, hyperorality, sexual hyperactivity, changes in dietary behavior, and hypermetamorphosis. The purpose of this article was to identify and synthesize the available evidence from case reports and case series on the treatment profile of KBS among adolescents and adults after TBI. Four bibliographic databases (MEDLINE OVID, EMBASE, PsycINFO, and SCOPUS) were searched for relevant literature. No date or language restrictions were applied. All case reports containing original data on KBS following TBI among adolescents and adults were included. Articles were evaluated, and data were extracted according to predefined criteria. The literature search identified 24 case reports of KBS post-TBI published between 1968 and 2017. Most case subjects were male (70.1%), and the mean age at injury was 25.1 years (range, 13–67 years). Injury to one or both temporal lobes occurred in most cases. Inappropriate sexual hyperactivity was the most common KBS symptom, followed by a change in dietary behavior and hyperorality. Visual agnosia was the least reported. In 50% of cases, the patient fully recovered from KBS. One-half of all participants described pharmacological management; the most common medication prescribed was carbamazepine. Overall, there was a lack of data available on pharmacotherapy initiation and duration. The complex presentation of KBS presents challenges in terms of treatment options. Although overall individuals who were prescribed carbamazepine had positive outcomes, given the reliance on case reports, it is difficult to make a definitive recommendation to guide clinical practice.en_US
dc.description.sponsorshipInstitute for Safety, Compensation and Recovery Research, Monash University, Bionomics,Eli Lilly, Lundbeck, Novartis, Servieren_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1176/appi.neuropsych.18050112en_US
dc.rights© 2018 American Psychiatric Association Publishing. Reproduced in accordance with the publisher's self-archiving policy. The official published article is available online at https://doi.org/10.1176/appi.neuropsych.18050112.
dc.subjectKlüver-Bucy syndromeen_US
dc.subjectKBSen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectTBIen_US
dc.subjectAdolescentsen_US
dc.subjectAdultsen_US
dc.titleKlüver-Bucy Syndrome following traumatic brain injury: a systematic synthesis and review of pharmacological treatment from cases in adolescents and adultsen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-06-24
dc.date.application2018-10-31
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
refterms.dateFOA2018-11-21T11:44:37Z


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