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dc.contributor.authorLawrence, R.L.*
dc.contributor.authorHughes, Zak E.*
dc.contributor.authorCendan, V.J.*
dc.contributor.authorLiu, Y.*
dc.contributor.authorLim, C.K.*
dc.contributor.authorPrasad, P.N.*
dc.contributor.authorSwihart, M.T.*
dc.contributor.authorWalsh, T.R.*
dc.contributor.authorKnecht, M.R.*
dc.date.accessioned2018-09-21T13:21:46Z
dc.date.available2018-09-21T13:21:46Z
dc.date.issued2018-10
dc.identifier.citationLawrence RL, Hughes ZE and Cendan VJ et al (2018) Optical control of nanoparticle catalysis influenced by photoswitch positioning in hybrid peptide capping ligands. ACS Applied Materials & Interfaces. 10(39): 33640-33651.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16580
dc.descriptionYesen_US
dc.description.abstractHere we present an in-depth analysis of structural factors that modulate peptide-capped nanoparticle catalytic activity via optically driven structural reconfiguration of the biointerface present at the particle surface. Six different sets of peptide-capped Au nanoparticles were prepared, in which an azobenzene photoswitch was incorporated into one of two well-studied peptide sequences with known affinity for Au, each at one of three different positions: The N- or C-terminus, or mid-sequence. Changes in the photoswitch isomerization state induce a reversible structural change in the surface-bound peptide, which modulates the catalytic activity of the material. This control of reactivity is attributed to changes in the amount of accessible metallic surface area available to drive the reaction. This research specifically focuses on the effect of the peptide sequence and photoswitch position in the biomolecule, from which potential target systems for on/off reactivity have been identified. Additionally, trends associated with photoswitch position for a peptide sequence (Pd4) have been identified. Integrating the azobenzene at the N-terminus or central region results in nanocatalysts with greater reactivity in the trans and cis conformations, respectively; however, positioning the photoswitch at the C-terminus gives rise to a unique system that is reactive in the trans conformation and partially deactivated in the cis conformation. These results provide a fundamental basis for new directions in nanoparticle catalyst development to control activity in real time, which could have significant implications in the design of catalysts for multistep reactions using a single catalyst. Additionally, such a fine level of interfacial structural control could prove to be important for applications beyond catalysis, including biosensing, photonics, and energy technologies that are highly dependent on particle surface structures.en_US
dc.description.sponsorshipAir Office of Scientific Research, grant number FA9550-12- 1-0226.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1021/acsami.8b10582en_US
dc.rights© 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.8b10582en_US
dc.subjectAu nanoparticlesen_US
dc.subjectPeptidesen_US
dc.subjectBiointerface reconfigurationen_US
dc.subjectCatalysisen_US
dc.subjectPhotoactivated switchen_US
dc.titleOptical control of nanoparticle catalysis influenced by photoswitch positioning in hybrid peptide capping ligandsen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-09-05
dc.date.application2018-09-06
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-09-21T13:21:49Z


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