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dc.contributor.authorWang, E.H.C.*
dc.contributor.authorSantos, L.*
dc.contributor.authorLi, X.Y.*
dc.contributor.authorTran, A.*
dc.contributor.authorKim, S.S.Y.*
dc.contributor.authorWoo, K.*
dc.contributor.authorShapiro, J.*
dc.contributor.authorMcElwee, Kevin J.*
dc.date.accessioned2018-09-03T15:52:48Z
dc.date.available2018-09-03T15:52:48Z
dc.date.issued2018-09
dc.identifier.citationWang EHC, Santos L, Li XY et al (2018) Alopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I. Acta Dermato-Venereologica. 98(8): 776-782.
dc.identifier.urihttp://hdl.handle.net/10454/16565
dc.descriptionYes
dc.description.abstractThe development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and Creactive protein, in alopecia areata and androgenetic alopecia-affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. The mean plasma cardiac troponin I level was highest in alopecia areata subjects, moderately higher in androgenetic alopecia subjects, and lowest in subjects without hair loss (p < 0.05). Alopecia areata subjects not receiving treatments had highest levels of cardiac troponin I (p < 0.05). Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. The results suggest the potential for increased heart remodelling. Close monitoring of cardiovascular health in alopecia areata subjects, as well as subsets of androgenetic alopecia patients, may be appropriate.
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR; MOP-82927). EW is the recipient of a Banting Postdoctoral Fellowship (SAC-92845).
dc.language.isoen
dc.rights© 2018 Acta Dermato-Venereologica. Reproduced in accordance with the publisher's self-archiving policy. This is an open access article under the CC BY-NC license.
dc.subjectAlopecia areata
dc.subjectAndrogenetic alopecia
dc.subjectAutoimmune disease
dc.subjectCardiac troponin I
dc.subjectC-reactive protein
dc.subjectHeart remodelling
dc.subjectCardiovascular disease
dc.subjectHair loss
dc.titleAlopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I
dc.status.refereedYes
dc.date.Accepted2018-04-11
dc.date.application2018-05-08
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.2340/00015555-2964
dc.rights.licenseCC-BY-NC
refterms.dateFOA2018-09-03T15:52:52Z
dc.openaccess.statusopenAccess


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