Show simple item record

dc.contributor.authorWang, E.H.C.*
dc.contributor.authorSantos, L.*
dc.contributor.authorLi, X.Y.*
dc.contributor.authorTran, A.*
dc.contributor.authorKim, S.S.Y.*
dc.contributor.authorWoo, K.*
dc.contributor.authorShapiro, J.*
dc.contributor.authorMcElwee, Kevin J.*
dc.date.accessioned2018-09-03T15:52:48Z
dc.date.available2018-09-03T15:52:48Z
dc.date.issued2018-09
dc.identifier.citationWang EHC, Santos L, Li XY et al (2018) Alopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I. Acta Dermato-Venereologica. 98(8): 776-782.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16565
dc.descriptionYesen_US
dc.description.abstractThe development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and Creactive protein, in alopecia areata and androgenetic alopecia-affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. The mean plasma cardiac troponin I level was highest in alopecia areata subjects, moderately higher in androgenetic alopecia subjects, and lowest in subjects without hair loss (p < 0.05). Alopecia areata subjects not receiving treatments had highest levels of cardiac troponin I (p < 0.05). Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. The results suggest the potential for increased heart remodelling. Close monitoring of cardiovascular health in alopecia areata subjects, as well as subsets of androgenetic alopecia patients, may be appropriate.en_US
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR; MOP-82927). EW is the recipient of a Banting Postdoctoral Fellowship (SAC-92845).en_US
dc.language.isoenen_US
dc.rights© 2018 Acta Dermato-Venereologica. Reproduced in accordance with the publisher's self-archiving policy. This is an open access article under the CC BY-NC license.en_US
dc.subjectAlopecia areataen_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectAutoimmune diseaseen_US
dc.subjectCardiac troponin Ien_US
dc.subjectC-reactive proteinen_US
dc.subjectHeart remodellingen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectHair lossen_US
dc.titleAlopecia areata is associated with increased expression of heart disease biomarker cardiac troponin Ien_US
dc.status.refereedYesen_US
dc.date.Accepted2018-04-11
dc.date.application2018-05-08
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
dc.identifier.doihttps://doi.org/10.2340/00015555-2964
refterms.dateFOA2018-09-03T15:52:52Z


Item file(s)

Thumbnail
Name:
McElwee_ADV.pdf
Size:
1.710Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record