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    Alopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I

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    Publication date
    2018-09
    Author
    Wang, E.H.C.
    Santos, L.
    Li, X.Y.
    Tran, A.
    Kim, S.S.Y.
    Woo, K.
    Shapiro, J.
    McElwee, Kevin J.
    Keyword
    Alopecia areata
    Androgenetic alopecia
    Autoimmune disease
    Cardiac troponin I
    C-reactive protein
    Heart remodelling
    Cardiovascular disease
    Hair loss
    Rights
    © 2018 Acta Dermato-Venereologica. Reproduced in accordance with the publisher's self-archiving policy. This is an open access article under the CC BY-NC license.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and Creactive protein, in alopecia areata and androgenetic alopecia-affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. The mean plasma cardiac troponin I level was highest in alopecia areata subjects, moderately higher in androgenetic alopecia subjects, and lowest in subjects without hair loss (p < 0.05). Alopecia areata subjects not receiving treatments had highest levels of cardiac troponin I (p < 0.05). Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. The results suggest the potential for increased heart remodelling. Close monitoring of cardiovascular health in alopecia areata subjects, as well as subsets of androgenetic alopecia patients, may be appropriate.
    URI
    http://hdl.handle.net/10454/16565
    Version
    published version paper
    Citation
    Wang EHC, Santos L, Li XY et al (2018) Alopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I. Acta Dermato-Venereologica. 98(8): 776-782.
    Link to publisher’s version
    https://doi.org/10.2340/00015555-2964
    Type
    Article
    Collections
    Life Sciences Publications

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