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dc.contributor.authorJalili, R.B.*
dc.contributor.authorKilani, R.T.*
dc.contributor.authorLi, Y.*
dc.contributor.authorKhosravi-maharlooie, M.*
dc.contributor.authorNabai, L.*
dc.contributor.authorWang, E.H.C.*
dc.contributor.authorMcElwee, Kevin J.*
dc.contributor.authorGhahary, A.*
dc.date.accessioned2018-08-28T15:22:33Z
dc.date.available2018-08-28T15:22:33Z
dc.date.issued2018-06
dc.identifier.citationJalili RB, Kilani RT, Li Y et al (2018) Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model. Cell Transplantation. 27(6): 994-1004.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16554
dc.descriptionYesen_US
dc.description.abstractAlopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. A single intraperitoneal (IP) injection of IDO-expressing primary dermal fibroblasts was given to C3H/HeJ mice at the time of AA induction. While 60–70% of mice that received either control fibroblasts or vehicle injections developed extensive AA, none of the IDO-expressing fibroblast-treated mice showed new hair loss up to 20 weeks post injection. IDO cell therapy significantly reduced infiltration of CD4+ and CD8+ T cells into hair follicles and resulted in decreased expression of TNF-α, IFN-γ and IL-17 in the skin. Skin draining lymph nodes of IDO fibroblast-treated mice were significantly smaller, with more CD4+ CD25+ FoxP3+ regulatory T cells and fewer Th17 cells than those of control fibroblast and vehicle-injected mice. These findings indicate that IP injected IDO-expressing dermal fibroblasts can control inflammation and thereby prevent AA hair loss.en_US
dc.description.sponsorshipCanadian Institutes of Health Researches (Funding Reference Number: 134214 and 136945).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1177/0963689718773311en_US
dc.rights© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).en_US
dc.subjectAlopecia areataen_US
dc.subjectFibroblastsen_US
dc.subjectCell therapyen_US
dc.subjectHair folliclesen_US
dc.subjectAutoimmunityen_US
dc.subjectImmune toleranceen_US
dc.subjectIndoleamine 2en_US
dc.subject3-dioxygenaseen_US
dc.titleFibroblast cell-based therapy prevents induction of alopecia areata in an experimental modelen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-03-09
dc.date.application2018-06-05
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-08-28T15:22:36Z


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