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dc.contributor.authorAllison, S.J.*
dc.contributor.authorCooke, D.*
dc.contributor.authorDavidson, F.S.*
dc.contributor.authorElliott, P.I.P.*
dc.contributor.authorFaulkner, R.A.*
dc.contributor.authorGriffiths, H.B.S.*
dc.contributor.authorHarper, O.J.*
dc.contributor.authorHussain, O.*
dc.contributor.authorOwen-Lynch, P.J.*
dc.contributor.authorPhillips, Roger M.*
dc.contributor.authorRice, C.R.*
dc.contributor.authorShepherd, S.L.*
dc.contributor.authorWheelhouse, Richard T.*
dc.date.accessioned2018-08-22T13:42:10Z
dc.date.available2018-08-22T13:42:10Z
dc.date.issued2018-07-26
dc.identifier.citationAllison SJ, Cooke D, Davidson FS et al (2018) Ruthenium-containing linear helicates and mesocates with tuneable p53 selective cytotoxicity in colorectal cancer cells. Angewandte Chemie - International Edition. 57(31): 9799-9804.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16548
dc.descriptionYesen_US
dc.description.abstractThe ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2(L1)2]4+ was preferentially cytotoxic to isogenic cells (HCT116 p53−/−), which lack the critical tumour suppressor gene. The mesocate isomer shows the reverse selectivity, with the achiral isomer being preferentially cytotoxic towards HCT116 p53+/+. Other structurally similar RuII‐containing dinuclear complexes showed very little cytotoxic activity. This study demonstrates that alterations in ligand or isomer can have profound effects on cytotoxicity towards cancer cells of different p53 status and suggests that selectivity can be “tuned” to either genotype. In the search for compounds that can target difficult‐to‐treat tumours that lack the p53 tumour suppressor gene, [Ru2(L1)2]4+ is a promising compound for further development.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1002/anie.201805510en_US
dc.rights© 2018 Wiley This is the peer reviewed version of the following article: Allison SJ, Cooke D, Davidson FS et al (2018) Ruthenium-containing linear helicates and mesocates with tuneable p53 selective cytotoxicity in colorectal cancer cells. Angewandte Chemie - International Edition. 57(31): 9799-9804, which has been published in final form at https://doi.org/10.1002/anie.201805510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectCanceren_US
dc.subjectCytotoxicityen_US
dc.subjectHelicateen_US
dc.subjectMesocateen_US
dc.subjectRutheniumen_US
dc.titleRuthenium-containing linear helicates and mesocates with tuneable p53 selective cytotoxicity in colorectal cancer cellsen_US
dc.status.refereedYesen_US
dc.date.Accepted2018
dc.date.application2018-06-04
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-08-22T13:42:14Z


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