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dc.contributor.authorZhang, J.*
dc.contributor.authorMa, A.*
dc.contributor.authorShang, Lijun*
dc.date.accessioned2018-08-07T08:42:39Z
dc.date.available2018-08-07T08:42:39Z
dc.date.issued2018-05-29
dc.identifier.citationZhang J, Ma A and Shang L (2018) Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases. Frontiers in Physiology. 9:642.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16530
dc.descriptionYesen_US
dc.description.abstractDeveloping new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such as heart failure and endocarditis have provided hopes for better drug delivery and reducing of drug side-effects. In this mini-review, we summarize the present applications of using gold nanoparticles (GNPs) as a new drug delivery system in diseased hearts and of the assessment of toxicity in using GNPs. We suggest that conjugating existing clinical drugs with GNPs is a favorable choice to provide “new and double-enhanced” potentiality to those existing drugs in treating heart diseases. Other applications of using NPs in the treatment of heart diseases including using drugs in nano-form and coating drugs with a surface of relevant NP are also discussed.en_US
dc.language.isoenen_US
dc.rights© 2018 Zhang, Ma and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectNanoparticlesen_US
dc.subjectGold nanoparticlesen_US
dc.subjectHeart diseasesen_US
dc.subjectDrugsen_US
dc.subjectAnimal modelsen_US
dc.titleConjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseasesen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-05-11
dc.date.application2018-05-29
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.00642
refterms.dateFOA2018-08-07T08:42:43Z


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