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    Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs

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    Publication date
    2018
    Author
    Seaton, Colin C.
    Rayan, R.T.
    Essifaow, E.A.A.
    Nauha, E.
    Munshi, Tasnim
    Scowen, Ian J.
    Keyword
    Salts
    Sulfathiazole
    Crystal engineering
    Rights
    (c) 2018 Royal Society of Chemistry. Full-text reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The creation of salts is a frequently used approach for the modification of physicochemical properties of an active pharmaceutical ingredient. Despite the frequency of application, there has been little research into the structural-property relationships of the final material and the nature of the counterion present. This work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions with variation in the crystal packing motifs.
    URI
    http://hdl.handle.net/10454/16328
    Version
    Accepted Manuscript
    Citation
    Seaton CC, Thomas RR, Essfaow EAA et al (2018) Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs. CrystEngComm. 20(24): 3428-3434.
    Link to publisher’s version
    https://doi.org/10.1039/C8CE00606G
    Type
    Article
    Collections
    Life Sciences Publications

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