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dc.contributor.authorDenniss, Jonathan*
dc.contributor.authorSchiessl, I.*
dc.contributor.authorNourrit, V.*
dc.contributor.authorFenerty, C.H.*
dc.contributor.authorGautam, R.*
dc.contributor.authorHenson, D.B.*
dc.date.accessioned2018-06-26T07:54:34Z
dc.date.available2018-06-26T07:54:34Z
dc.date.issued2011-11
dc.identifier.citationDenniss J, Schiessl I, Nourrit V et al (2011) Relationships between Visual Field Sensitivity and Spectral Absorption Properties of the Neuroretinal Rim in Glaucoma by Multispectral Imaging. Investigative Ophthalmology and Visual Science. 52(12): 8732-8738.en_US
dc.identifier.urihttp://hdl.handle.net/10454/16320
dc.descriptionNoen_US
dc.description.abstractTo investigate the relationship between neuroretinal rim (NRR) differential light absorption (DLA, a measure of spectral absorption properties) and visual field (VF) sensitivity in primary open-angle glaucoma (POAG). atients diagnosed with (n = 22) or suspected of having (n = 7) POAG were imaged with a multispectral system incorporating a modified digital fundus camera, 250-W tungsten-halogen lamp, and fast-tuneable liquid crystal filter. Five images were captured sequentially within 1.0 second at wavelengths selected according to absorption properties of hemoglobin (range, 570–610 nm), and a Beer-Lambert law model was used to produce DLA maps of residual NRR from the images. Patients also underwent VF testing. Differences in NRR DLA in vertically opposing 180° and 45° sectors either side of the horizontal midline were compared with corresponding differences in VF sensitivity on both decibel and linear scales by Spearman's rank correlation. The decibel VF sensitivity scale showed significant relationships between superior–inferior NRR DLA difference and sensitivity differences between corresponding VF areas in 180° NRR sectors (Spearman ρ = 0.68; P < 0.0001), superior-/inferior-temporal 45° NRR sectors (ρ = 0.57; P < 0.002), and superior-/inferior-nasal 45° NRR sectors (ρ = 0.59; P < 0.001). Using the linear VF sensitivity scale significant relationships were found for 180° NRR sectors (ρ = 0.62; P < 0.0002) and superior–inferior–nasal 45° NRR sectors (ρ = 0.53; P < 0.002). No significant difference was found between correlations using the linear or decibel VF sensitivity scales. Residual NRR DLA is related to VF sensitivity in POAG. Multispectral imaging may provide clinically important information for the assessment and management of POAG.en_US
dc.description.sponsorshipCollege of Optometrists (UK) PhD Studentship (JD), Central Manchester NHS Foundation Trust Grant RO1180, the Manchester Academic Health Sciences Centre (MAHSC), and the NIHR Manchester Biomedical Research Centre.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1167/iovs.11-8302en_US
dc.subjectVisual field sensitivityen_US
dc.subjectSpectral absorption propertiesen_US
dc.subjectNeuroretinal rimen_US
dc.subjectGlaucomaen_US
dc.subjectMultispectral imagingen_US
dc.titleRelationships between Visual Field Sensitivity and Spectral Absorption Properties of the Neuroretinal Rim in Glaucoma by Multispectral Imagingen_US
dc.status.refereedYesen_US
dc.date.application2011-11-07
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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