Mechanistic Insights into the Stabilisation of Biopharmaceuticals using Glycine Derivatives. The Effect of Glycine Derivatives on the Crystallisation, Physical Properties and Behaviour of Commonly used Excipients to Stabilise Antigens, Adjuvants and Proteins in the Solid State

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PhD Thesis (6.250Mb)
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Publication date
2015Author
Bright, Andrew G.Supervisor
Isreb, MohammadKeyword
Freeze dryingGlycine derivatives
Differential scanning calorimetry (DSC)
Powder X-Ray diffraction (P-XRD)
Raman spectroscopy
Crystallisation
Water loss
Vaccines
Adjuvant
Stabilisation
Amorphous
Gordon-Taylor equation
Solubility parameters
Karl Fischer
Excipients
Proteins
DLS (Dynamic Light Scattering)
Polymorphs
Vaccines
Formulation
Mannitol
Sucrose
Biopharmaceuticals
Rights

The University of Bradford theses are licenced under a Creative Commons Licence.
Institution
University of BradfordDepartment
School of Pharmacy, Faculty of Life SciencesAwarded
2015