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dc.contributor.authorReuber, M.*
dc.contributor.authorBlackburn, D.*
dc.contributor.authorElsey, C.*
dc.contributor.authorWakefield, S.*
dc.contributor.authorArdern, K.*
dc.contributor.authorHarkness, K.*
dc.contributor.authorVenneri, A.*
dc.contributor.authorJones, Danielle K.*
dc.contributor.authorShaw, C.*
dc.contributor.authorDrew, P.*
dc.date.accessioned2018-05-16T11:25:42Z
dc.date.available2018-05-16T11:25:42Z
dc.date.issued2018-07-01
dc.identifier.citationReuber M, Blackburn D, Elsey C et al (2018) An interactional profile to assist the differential diagnosis of neurodegenerative and functional memory disorders. Alzheimer Disease & Associated Disorders. 32(3): 197-206.en_US
dc.identifier.urihttp://hdl.handle.net/10454/15909
dc.descriptionYesen_US
dc.description.abstractSpecialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behaviour of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with Functional Memory Disorder (FMD). In Part 1 of this study, a Diagnostic Scoring Aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features. An optimal cut-off differentiating ND and FMD was established by applying the DSA to 30 initial patient-doctor memory clinic encounters. In Part 2, the DSA was tested prospectively in ten additional cases analysed independently by two Conversation Analysts blinded to medical information. In part one, the median score of the DSA was +5 in ND and -5 in FMD (p<0.001). The optimal numeric DSA cut off (+1) identified patients with ND with a sensitivity of 86.7% and a specificity of 100%. In part two, DSA scores of rater one correctly predicted 10/10 and those of rater two 9/10 diagnoses. This study indicates that interactional and linguistic features can help distinguish between patients developing dementia and those with FMD and could aid the stratification of patients with memory problems.en_US
dc.description.sponsorshipNIHR Research for Patient Benefit (RfPB) Programme: PB-PG-0211-24079 – Using Conversation Analysis in the Differential Diagnosis of Memory Problems: a pilot study. 2013-2015en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1097/WAD.0000000000000231en_US
dc.rights(c) 2018 Wolters Kluwer. Full-text of the final accepted manuscript reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectDementiaen_US
dc.subjectScreeningen_US
dc.subjectFunctional memory disorderen_US
dc.titleAn interactional profile to assist the differential diagnosis of neurodegenerative and functional memory disordersen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-10-26
dc.date.application2018-01-09
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US


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