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dc.contributor.authorPalafox-Hernandez, J.P.*
dc.contributor.authorLim, C-K.*
dc.contributor.authorTang, Z.*
dc.contributor.authorDrew, K.L.M.*
dc.contributor.authorHughes, Zak E.*
dc.contributor.authorLi, Y.*
dc.contributor.authorSwihart, M.T.*
dc.contributor.authorPrasad, P.N.*
dc.contributor.authorKnecht, M.R.*
dc.contributor.authorWalsh, T.R.*
dc.date.accessioned2018-05-09T08:54:11Z
dc.date.available2018-05-09T08:54:11Z
dc.date.issued2016-01-13
dc.identifier.citationPalafox-Hernandez, JP, Lim C-K, Tang Z (2016) Optical actuation of inorganic/organic interfaces: comparing peptide-azobenzene ligand reconfiguration on gold and silver nanoparticles. ACS Applied Materials and Interfaces. 8(1): 1050-1060.en_US
dc.identifier.urihttp://hdl.handle.net/10454/15820
dc.descriptionYesen_US
dc.description.abstractPhotoresponsive molecules that incorporate peptides capable of material-specific recognition provide a basis for biomolecule-mediated control of the nucleation, growth, organization, and activation of hybrid inorganic/organic nanostructures. These hybrid molecules interact with the inorganic surface through multiple noncovalent interactions which allow reconfiguration in response to optical stimuli. Here, we quantify the binding of azobenzene-peptide conjugates that exhibit optically triggered cis-trans isomerization on Ag surfaces and compare to their behavior on Au. These results demonstrate differences in binding and switching behavior between the Au and Ag surfaces. These molecules can also produce and stabilize Au and Ag nanoparticles in aqueous media where the biointerface can be reproducibly and reversibly switched by optically triggered azobenzene isomerization. Comparisons of switching rates and reversibility on the nanoparticles reveal differences that depend upon whether the azobenzene is attached at the peptide N- or C-terminus, its isomerization state, and the nanoparticle composition. Our integrated experimental and computational investigation shows that the number of ligand anchor sites strongly influences the nanoparticle size. As predicted by our molecular simulations, weaker contact between the hybrid biomolecules and the Ag surface, with fewer anchor residues compared with Au, gives rise to differences in switching kinetics on Ag versus Au. Our findings provide a pathway toward achieving new remotely actuatable nanomaterials for multiple applications from a single system, which remains difficult to achieve using conventional approaches.en_US
dc.description.sponsorshipAir Office of Scientific Research, grant number FA9550-12-1-0226.en_US
dc.language.isoenen_US
dc.rights© 2016 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsami.5b11989en_US
dc.subjectBionanocombinatorics; Peptides; Conformational switching; Nanoparticles; Azobenzeneen_US
dc.titleOptical actuation of inorganic/organic interfaces: comparing peptide-azobenzene ligand reconfiguration on gold and silver nanoparticlesen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-12-18
dc.date.application2015-12-18
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1021/acsami.5b11989
refterms.dateFOA2018-07-28T03:57:04Z


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