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dc.contributor.authorSnaith, Beverly*
dc.contributor.authorHarris, Martine A.*
dc.contributor.authorShinkins, B.*
dc.contributor.authorJordaan, M.*
dc.contributor.authorMessenger, M.*
dc.contributor.authorLewington, A.*
dc.date.accessioned2018-04-27T13:08:21Z
dc.date.available2018-04-27T13:08:21Z
dc.date.issued2018
dc.identifier.citationSnaith B, Harris MA, Shinkins B et al (2018) Point-of-care creatinine testing for kidney function measurement prior to contrast-enhanced diagnostic imaging: evaluation of the performance of three systems for clinical utility. Clinical Chemistry and Laboratory Medicine. 56(8): 1269-1276.en_US
dc.identifier.urihttp://hdl.handle.net/10454/15685
dc.descriptionYesen_US
dc.description.abstractAcute kidney injury (AKI) can occur rarely in patients exposed to iodinated contrast and result in contrast-induced AKI (CI-AKI). A key risk factor is the presence of pre-existing chronic kidney disease (CKD), therefore it is important to assess patient risk and obtain kidney function measurement prior to administration. Point of care (PoC) testing provides an alternative strategy but there remains uncertainty, with respect to diagnostic accuracy and clinical utility. A device study compared three PoC analysers (Nova StatSensor, Abbott i-STAT, Radiometer ABL800 FLEX) with a reference laboratory standard (Roche Cobas 8000 series, enzymatic creatinine). Three hundred adult patients attending a UK hospital phlebotomy department were recruited to have additional blood samples for analysis on the PoC devices. The ABL800 FLEX had the strongest concordance with laboratory measured serum creatinine (mean bias=-0.86, 95% limits of agreement = -9.6 to 7.9) followed by the i-STAT (average bias=3.88, 95% limits of agreement = -8.8 to 16.6) and StatSensor (average bias=3.56, 95% limits of agreement = -27.7 to 34.8). In risk classification, the ABL800 FLEX and i-STAT identified all patients with an eGFR≤30, whereas the StatSensor resulted in a small number of missed high-risk cases (n=4/13) and also operated outside of the established performance goals. The screening of patients at risk of CI-AKI may be feasible with PoC technology. However in this study it was identified that the analyser concordance with the laboratory reference varies. It is proposed that further research exploring PoC implementation in imaging department pathways is needed.en_US
dc.description.sponsorshipYorkshire and Humber Academic Health Science Network (Grant Number: YHP0318)en_US
dc.language.isoenen_US
dc.rights© 2018 Walter de Gruyter GmbH. Full-text reproduced in accordance with the publisher’s self-archiving policy.en_US
dc.subjectContrast-induced acute kidney injuryen_US
dc.subjectContrast media
dc.subjectCreatinine
dc.subjectDiagnostic imaging
dc.subjectEstimated glomerular filtration rate
dc.subjectKidney diseases
dc.subjectPoint-of-care testing
dc.titlePoint-of-care creatinine testing for kidney function measurement prior to contrast-enhanced diagnostic imaging: evaluation of the performance of three systems for clinical utilityen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-02-28
dc.date.application2018-04-19
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1515/cclm-2018-0128
refterms.dateFOA2019-04-24T07:50:37Z


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