Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation
dc.contributor.author | Weiland, D. | * |
dc.contributor.author | Brachvogel, B. | * |
dc.contributor.author | Hornig-Do, H.-T. | * |
dc.contributor.author | Neuhaus, J.F.G. | * |
dc.contributor.author | Holzer, T. | * |
dc.contributor.author | Tobin, Desmond J. | * |
dc.contributor.author | Niessen, C.N. | * |
dc.contributor.author | Wiesner, R.J. | * |
dc.contributor.author | Baris, O.R. | * |
dc.date.accessioned | 2018-04-23T15:13:35Z | |
dc.date.available | 2018-04-23T15:13:35Z | |
dc.date.issued | 2018-01 | |
dc.identifier.citation | Weiland D, Brachvogel B, Hornig-Do H-T et al (2018) Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. Journal of Investigative Dermatology. 138(1): 132-140. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/15612 | |
dc.description | No | en_US |
dc.description.abstract | Accumulation of large-scale mitochondrial DNA (mtDNA) deletions and chronic, subclinical inflammation are concomitant during skin aging, thus raising the question of a causal link. To approach this, we generated mice expressing a mutant mitochondrial helicase (K320E-TWINKLE) in the epidermis to accelerate the accumulation of mtDNA deletions in this skin compartment. Mice displayed low amounts of large-scale deletions and a dramatic depletion of mtDNA in the epidermis and showed macroscopic signs of severe skin inflammation. The mtDNA alterations led to an imbalanced stoichiometry of mitochondrial respiratory chain complexes, inducing a unique combination of cytokine expression, causing a severe inflammatory phenotype, with massive immune cell infiltrates already before birth. Altogether, these data unraveled a previously unknown link between an imbalanced stoichiometry of the mitochondrial respiratory chain complexes and skin inflammation and suggest that severe respiratory chain dysfunction, as observed in few cells leading to a mosaic in aged tissues, might be involved in the development of chronic subclinical inflammation. | en_US |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (Wi 889/6-3 to RJW, SFB 829 A14 to RJW, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases–CECAD to RJW, BR2304/9-1 to BB, and SFB 829 A1, A5, and Z2 to CMN) and the Center of Molecular Medicine Cologne of the Medical Faculty (CMMC, to RJW) | en_US |
dc.language.iso | en | en_US |
dc.relation.isreferencedby | https://doi.org/10.1016/j.jid.2017.08.019 | en_US |
dc.subject | mtDNA; Mitochondrial DNA; RC; Respiratory chain; ROS; Reactive oxygen; Species | en_US |
dc.title | Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation | en_US |
dc.status.refereed | Yes | en_US |
dc.date.Accepted | 2017-08-16 | |
dc.date.application | 2017-09-01 | |
dc.type | Article | en_US |
dc.type.version | No full-text in the repository | en_US |