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    CNGB3 mutations cause severe rod dysfunction

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    maguire_et_al_2017.pdf (918.3Kb)
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    Publication date
    2018
    Author
    Maguire, John
    McKibbin, M.
    Khan, K.
    Ali, M.
    Kohl, S.
    McKeefry, Declan J.
    Keyword
    Achromatopsia; Electroretinogram; Rods
    Rights
    © 2018 Taylor & Francis. The Version of Record of this manuscript has been published and is available in Ophthalmic Genetics in 2018 at https://doi.org/10.1080/13816810.2017.1368087.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Congenital achromatopsia or rod monochromatism is a rare autosomal recessive condition defined by a severe loss of cone photoreceptor function in which rods purportedly retain normal or near-to-normal function. This report describes the results of electroretinography in two siblings with CNGB3-associated achromatopsia. Full field light- and dark-adapted electroretinograms (ERGs) were recorded using standard protocols detailed by the International Society for Clinical Electrophysiology of Vision (ISCEV). We also examined rod-mediated ERGs using series of stimuli that varied over a 6 log unit range of retinal illuminances (−1.9–3.5 log scotopic trolands). Dark-adapted ERGs in achromatopsia patients exhibited severely reduced b-wave amplitudes with abnormal b:a ratios (1.3 and 0.6). In comparison, the reduction in a-wave amplitude was less marked. The rod-mediated ERG took on an electronegative appearance at high-stimulus illuminances. Although the defect that causes achromatopsia is primarily in the cone photoreceptors, our results reveal an accompanying disruption of rod function that is more severe than has previously been reported. The differential effects on the b-wave relative to the a-wave points to an inner-retinal locus for the disruption of rod function in these patients.
    URI
    http://hdl.handle.net/10454/15500
    Version
    Accepted Manuscript
    Citation
    Maguire J, McKibbin M, Kahn K et al (2018) CNGB3 mutations cause severe rod dysfunction. Ophthalmic Genetics. 39(1): 108-114.
    Link to publisher’s version
    https://doi.org/10.1080/13816810.2017.1368087
    Type
    Article
    Collections
    Life Sciences Publications

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