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dc.contributor.authorZele, A.
dc.contributor.authorFeigle, B.
dc.contributor.authorKambhampati, P.
dc.contributor.authorAher, A.
dc.contributor.authorMcKeefry, Declan J.
dc.contributor.authorParry, Neil R.A.
dc.contributor.authorMaguire, John
dc.contributor.authorMurray, I.J.
dc.contributor.authorKremers, Jan
dc.date.accessioned2018-04-13T14:46:11Z
dc.date.available2018-04-13T14:46:11Z
dc.date.issued2017-11
dc.identifier.citationMaguire J, Parry NRA, Kremers J et al (2017) A Temporal White Noise Analysis for Extracting the Impulse Response Function of the Human Electroretinogram. Translational Vision Science and Technology. 6(6), 1.en_US
dc.identifier.urihttp://hdl.handle.net/10454/15488
dc.descriptionYesen_US
dc.description.abstractPurpose: We introduce a method for determining the impulse response function (IRF) of the ERG derived from responses to temporal white noise (TWN) stimuli. Methods: This white noise ERG (wnERG) was recorded in participants with normal trichromatic vision to full-field (Ganzfeld) and 39.38 diameter focal stimuli at mesopic and photopic mean luminances and at different TWN contrasts. The IRF was obtained by cross-correlating the TWN stimulus with the wnERG. Results: We show that wnERG recordings are highly repeatable, with good signal-tonoise ratio, and do not lead to blink artifacts. The wnERG resembles a flash ERG waveform with an initial negativity (N1) followed by a positivity (P1), with amplitudes that are linearly related to stimulus contrast. These N1 and N1-P1 components showed commonalties in implicit times with the a- and b-waves of flash ERGs. There was a clear transition from rod- to cone-driven wnERGs at ~1 photopic cd.m 2. We infer that oscillatory potentials found with the flash ERG, but not the wnERG, may reflect retinal nonlinearities due to the compression of energy into a short time period during a stimulus flash. Conclusion: The wnERG provides a new approach to study the physiology of the retina using a stimulation method with adaptation and contrast conditions similar to natural scenes to allow for independent variation of stimulus strength and mean luminance, which is not possible with the conventional flash ERG. Translational Relevance: The white noise ERG methodology will be of benefit for clinical studies and animal models in the evaluation of hypotheses related to cellular redundancy to understand the effects of disease on specific visual pathways.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1167/tvst.6.6.1en_US
dc.rights(c) 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0)en_US
dc.subjectERG; Impulse response functionen_US
dc.titleA Temporal White Noise Analysis for Extracting the Impulse Response Function of the Human Electroretinogramen_US
dc.status.refereedYesen_US
dc.date.Accepted2017
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-28T03:43:11Z


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